Amanda J Kedaigle

Affiliations: 
Broad Institute of MIT and Harvard, USA 
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"Amanda Kedaigle"
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Parents

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Donald E. Elmore research assistant Wellesley
Ernest Fraenkel grad student MIT (Plant Biology Tree)
Paola Arlotta post-doc Harvard (Neurotree)
Joshua Levin research scientist Broad Institute
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Publications

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Pigoni M, Uzquiano A, Paulsen B, et al. (2023) Cell-type specific defects in PTEN-mutant cortical organoids converge on abnormal circuit activity. Human Molecular Genetics
Uzquiano A, Kedaigle AJ, Pigoni M, et al. (2022) Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex. Cell. 185: 3770-3788.e27
Paulsen B, Velasco S, Kedaigle AJ, et al. (2022) Autism genes converge on asynchronous development of shared neuron classes. Nature
Akimov SS, Jiang M, Kedaigle AJ, et al. (2021) Immortalized striatal precursor neurons from Huntington's disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics. Human Molecular Genetics
Ding J, Adiconis X, Simmons SK, et al. (2020) Author Correction: Systematic comparison of single-cell and single-nucleus RNA-sequencing methods. Nature Biotechnology
Ding J, Adiconis X, Simmons SK, et al. (2020) Systematic comparison of single-cell and single-nucleus RNA-sequencing methods. Nature Biotechnology
Kedaigle AJ, Reidling JC, Lim RG, et al. (2019) Treatment with JQ1, a BET bromodomain inhibitor, is selectively detrimental to R6/2 Huntington's disease mice. Human Molecular Genetics
Velasco S, Kedaigle AJ, Simmons SK, et al. (2019) Individual brain organoids reproducibly form cell diversity of the human cerebral cortex. Nature
Zonouzi M, Berger D, Jokhi V, et al. (2019) Individual Oligodendrocytes Show Bias for Inhibitory Axons in the Neocortex. Cell Reports. 27: 2799-2808.e3
Kedaigle AJ, Fraenkel E, Atwal RS, et al. (2019) Bioenergetic deficits in Huntington's disease iPSC-derived neural cells and rescue with glycolytic metabolites. Human Molecular Genetics
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