Carmine Coscia

1965-2014 Biochemistry and Molecular Biology Saint Louis University School of Medicine, St. Louis, MO, United States 
Opioid Biosynthesis and Mechanism of Action
"Carmine Coscia"

dob: July 26, 1935
Ph.D.: Mentor F. F. Nord
Postdoctoral Fellow: Duilio Arigoni

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Phamduong E, Rathore MK, Crews NR, et al. (2014) Acute and chronic mu opioids differentially regulate thrombospondins 1 and 2 isoforms in astrocytes. Acs Chemical Neuroscience. 5: 106-14
Ikeda H, Miyatake M, Koshikawa N, et al. (2010) Morphine modulation of thrombospondin levels in astrocytes and its implications for neurite outgrowth and synapse formation. The Journal of Biological Chemistry. 285: 38415-27
Hahn JW, Jagwani S, Kim E, et al. (2010) Mu and kappa opioids modulate mouse embryonic stem cell-derived neural progenitor differentiation via MAP kinases. Journal of Neurochemistry. 112: 1431-41
Miyatake M, Rubinstein TJ, McLennan GP, et al. (2009) Inhibition of EGF-induced ERK/MAP kinase-mediated astrocyte proliferation by mu opioids: integration of G protein and beta-arrestin 2-dependent pathways. Journal of Neurochemistry. 110: 662-74
McLennan GP, Kiss A, Miyatake M, et al. (2008) Kappa opioids promote the proliferation of astrocytes via Gbetagamma and beta-arrestin 2-dependent MAPK-mediated pathways. Journal of Neurochemistry. 107: 1753-65
Kim E, Clark AL, Kiss A, et al. (2006) Mu- and kappa-opioids induce the differentiation of embryonic stem cells to neural progenitors. The Journal of Biological Chemistry. 281: 33749-60
Hou Y, Belcheva MM, Clark AL, et al. (2006) Increased opioid receptor binding and G protein coupling in the accumbens and ventral tegmental area of postnatal day 2 rats. Neuroscience Letters. 395: 244-8
Belcheva MM, Clark AL, Haas PD, et al. (2005) Mu and kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes. The Journal of Biological Chemistry. 280: 27662-9
Hou Y, Tan Y, Belcheva MM, et al. (2004) Differential effects of gestational buprenorphine, naloxone, and methadone on mesolimbic mu opioid and ORL1 receptor G protein coupling. Brain Research. Developmental Brain Research. 151: 149-57
Belcheva MM, Tan Y, Heaton VM, et al. (2003) Mu opioid transactivation and down-regulation of the epidermal growth factor receptor in astrocytes: implications for mitogen-activated protein kinase signaling. Molecular Pharmacology. 64: 1391-401
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