Shailesh Natvarbhai Mistry

University of Nottingham, Nottingham, England, United Kingdom 
GPCRs, medicinal chemistry, allosteric ligands, chemical biology tools
"Shailesh Mistry"
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Stephen Hill grad student 2005-2008 Nottingham
Barrie Kellam grad student 2005-2008 Nottingham
Barrie Kellam post-doc 2008-2012 Nottingham
Peter Scammells post-doc 2012-2014 Monash University


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Sunil Rajput grad student 2013-2019 Nottingham
Timothy Fyfe grad student 2015-2019 University of Nottingham/Monash University
Emanuel Sousa grad student 2015-2020 Nottingham
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Mistry SN, Marchand P, Kellam B. (2019) 27th Annual GP2A Medicinal Chemistry Conference. Pharmaceuticals (Basel, Switzerland). 12
Fyfe TJ, Kellam B, Sykes DA, et al. (2019) Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D Receptor. Journal of Medicinal Chemistry
Fyfe TJ, Kellam B, Mistry SN, et al. (2019) Subtle modifications to a thieno[2,3-d]pyrimidine scaffold yield negative allosteric modulators and agonists of the dopamine D receptor. European Journal of Medicinal Chemistry. 168: 474-490
Fyfe TJ, Zarzycka B, Lim HD, et al. (2018) A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor. Journal of Medicinal Chemistry
Baker JG, Gardiner SM, Woolard J, et al. (2017) Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology
Choy KH, Shackleford DM, Malone DT, et al. (2016) Positive allosteric modulation of the muscarinic M1 receptor improves efficacy of antipsychotics in mouse glutamatergic deficit models of behavior. The Journal of Pharmacology and Experimental Therapeutics
Emtage AL, Mistry SN, Fischer PM, et al. (2016) GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors. Journal of Biomolecular Structure & Dynamics. 1-47
Mistry SN, Lim H, Jörg M, et al. (2016) Novel Fused Arylpyrimidinone Based Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor. Acs Chemical Neuroscience
Drinkwater N, Vinh NB, Mistry SN, et al. (2016) Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. European Journal of Medicinal Chemistry. 110: 43-64
Mistry SN, Jörg M, Lim H, et al. (2015) 4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor. Journal of Medicinal Chemistry
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