Adam R. Johnson

Affiliations: 
Genentech, Inc., San Francisco, CA, United States 
Area:
Immunology
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"Adam Johnson"
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Publications

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Labadie S, Barrett K, Blair WS, et al. (2013) Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 5923-30
Li JJ, Johnson AR. (2011) Selective MMP13 inhibitors. Medicinal Research Reviews. 31: 863-94
Schnute ME, O'Brien PM, Nahra J, et al. (2010) Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. Bioorganic & Medicinal Chemistry Letters. 20: 576-80
Li JJ, Nahra J, Johnson AR, et al. (2008) Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. Journal of Medicinal Chemistry. 51: 835-41
Johnson AR, Pavlovsky AG, Ortwine DF, et al. (2007) Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects. The Journal of Biological Chemistry. 282: 27781-91
Johnson AR, Marletta MA, Dyer RD. (2001) Slow-binding inhibition of human prostaglandin endoperoxide synthase-2 with darbufelone, an isoform-selective antiinflammatory di-tert-butyl phenol. Biochemistry. 40: 7736-45
Johnson LL, Pavlovsky AG, Johnson AR, et al. (2000) A rationalization of the acidic pH dependence for stromelysin-1 (Matrix metalloproteinase-3) catalysis and inhibition. The Journal of Biological Chemistry. 275: 11026-33
Wang Y, Johnson AR, Ye QZ, et al. (1999) Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain. The Journal of Biological Chemistry. 274: 33043-9
Johnson AR, Chen YW, Dekker EE. (1998) Investigation of a catalytic zinc binding site in Escherichia coli L-threonine dehydrogenase by site-directed mutagenesis of cysteine-38. Archives of Biochemistry and Biophysics. 358: 211-21
Johnson AR, Dekker EE. (1998) Site-directed mutagenesis of histidine-90 in Escherichia coli L-threonine dehydrogenase alters its substrate specificity. Archives of Biochemistry and Biophysics. 351: 8-16
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