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Adam R. Johnson

Affiliations: 
Genentech, Inc., San Francisco, CA, United States 
Area:
Immunology
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"Adam Johnson"
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Parents

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Eugene E. Dekker grad student 1991-1996 University of Michigan
Richard D. Dyer post-doc 1996-1999 Pfizer Global Research & Development
Michael A. Marletta post-doc 1996-1999 University of Michigan

Children

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Publications

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Crawford JJ, Lee W, Johnson AR, et al. (2020) Stereochemical Differences in Fluorocyclopropyl Amides Enable Tuning of Btk Inhibition and Off-Target Activity. Acs Medicinal Chemistry Letters. 11: 1588-1597
Patel S, Webster JD, Varfolomeev E, et al. (2019) RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases. Cell Death and Differentiation
Hamilton GL, Chen H, Deshmukh G, et al. (2019) Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group. Bioorganic & Medicinal Chemistry Letters
Zak M, Hanan EJ, Lupardus P, et al. (2019) Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorganic & Medicinal Chemistry Letters
Dengler HS, Wu X, Peng I, et al. (2018) Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma. Science Translational Medicine. 10
Reiff SD, Muhowski EM, Guinn D, et al. (2018) Non-covalent inhibition of C481S Bruton's tyrosine kinase by GDC-0853: a new treatment strategy for ibrutinib resistant CLL. Blood
Lo YC, Liu T, Morrissey KM, et al. (2018) Computational Analysis of Kinase Inhibitor Selectivity using Structural Knowledge. Bioinformatics (Oxford, England)
Huang CS, Oberbeck N, Hsiao YC, et al. (2018) Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity. Structure (London, England : 1993)
Crawford JJ, Johnson AR, Misner DL, et al. (2018) Discovery of GDC-0853, a Potent, Selective, and Non-Covalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development. Journal of Medicinal Chemistry
Brightbill HD, Suto E, Blaquiere N, et al. (2018) NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus. Nature Communications. 9: 179
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