Steven M. Johnson, Ph.D.
Affiliations: | Biochemistry and Molecular Biology | Indiana Univ. School of Medicine |
Area:
Chemical Biology / Medicinal ChemistryGoogle:
"Steven Johnson"Mean distance: 8.73 | S | N | B | C | P |
Parents
Sign in to add mentor| Jeffery W. Kelly | grad student | 2006 | Scripps Institute | |
| (The design, synthesis, and biophysical evaluation of small molecules to study and selectively inhibit transthyretin amyloidosis.) | ||||
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Publications
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| Stevens M, Howe C, Ray AM, et al. (2020) Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs. Bioorganic & Medicinal Chemistry. 28: 115710 |
| Ambrose AJ, Zerio CJ, Sivinski J, et al. (2019) A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78. Bioorganic & Medicinal Chemistry Letters |
| Washburn A, Abdeen S, Ovechkina Y, et al. (2019) Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections. Bioorganic & Medicinal Chemistry Letters |
| Stevens M, Abdeen S, Salim N, et al. (2019) HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. Bioorganic & Medicinal Chemistry Letters |
| Wu CX, Liao J, Park Y, et al. (2019) Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics. The Journal of Biological Chemistry |
| Kunkle T, Abdeen S, Salim N, et al. (2018) Hydroxybiphenylamide GroEL/ES inhibitors are potent antibacterials against planktonic and biofilm forms of Staphylococcus aureus. Journal of Medicinal Chemistry |
| Abdeen S, Kunkle T, Salim N, et al. (2018) Sulfonamido-2-arylbenzoxazole GroEL/ES inhibitors are potent antibacterials against methicillin-resistant Staphylococcus aureus (MRSA). Journal of Medicinal Chemistry |
| Connelly S, Mortenson DE, Choi S, et al. (2017) Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors. Bioorganic & Medicinal Chemistry Letters |
| Abdeen S, Salim N, Mammadova N, et al. (2016) Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness. Bioorganic & Medicinal Chemistry Letters |
| Abdeen S, Salim N, Mammadova N, et al. (2016) GroEL/ES inhibitors as potential antibiotics. Bioorganic & Medicinal Chemistry Letters. 26: 3127-34 |