Yosephine Gumulya
Affiliations: | Commonwealth Scientific and Industrial Research Organization (CSIRO) |
Area:
Protein engineering, directed evolution, synthetic biology, microbial engineeringGoogle:
"Yosephine Gumulya"Mean distance: (not calculated yet)
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Publications
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| Vinde MH, Cao D, Chesterfield RJ, et al. (2022) Ancestral sequence reconstruction of the CYP711 family reveals functional divergence in strigolactone biosynthetic enzymes associated with gene duplication events in monocot grasses. The New Phytologist |
| Harris KL, Thomson RES, Gumulya Y, et al. (2022) Ancestral Sequence Reconstruction of a Cytochrome P450 Family Involved in Chemical Defense Reveals the Functional Evolution of a Promiscuous, Xenobiotic-Metabolizing Enzyme in Vertebrates. Molecular Biology and Evolution. 39 |
| Zaugg J, Gumulya Y, Boden M, et al. (2018) The Effect of Binding on the Enantioselectivity of an Epoxide Hydrolase. Journal of Chemical Information and Modeling |
| Gumulya Y, Huang W, D'Cunha SA, et al. (2018) Engineering Thermostable CYP2D Enzymes for Biocatalysis Using Combinatorial Libraries of Ancestors for Directed Evolution (CLADE) Chemcatchem. 11: 841-850 |
| Zaugg J, Gumulya Y, Malde AK, et al. (2017) Learning epistatic interactions from sequence-activity data to predict enantioselectivity. Journal of Computer-Aided Molecular Design. 31: 1085-1096 |
| Kan SBJ, Huang X, Gumulya Y, et al. (2017) Genetically programmed chiral organoborane synthesis. Nature. 552: 132-136 |
| Harris KL, Thomson RES, Strohmaier SJ, et al. (2017) Determinants of thermostability in the cytochrome P450 fold. Biochimica Et Biophysica Acta |
| Gumulya Y, Gillam EM. (2017) Exploring the past and the future of protein evolution with ancestral sequence reconstruction: the 'retro' approach to protein engineering. The Biochemical Journal. 474: 1-19 |
| Zaugg J, Gumulya Y, Gillam EM, et al. (2014) Computational tools for directed evolution: a comparison of prospective and retrospective strategies. Methods in Molecular Biology (Clifton, N.J.). 1179: 315-33 |
| Gumulya Y, Sanchis J, Reetz MT. (2012) Many Pathways in Laboratory Evolution Can Lead to Improved Enzymes: How to Escape from Local Minima Chembiochem. 13: 1060-1066 |