Xiaochun Li

2017- Molecular Genetics University of Texas Southwestern Medical Center, Dallas, TX, United States 
Structural Biology
"Xiaochun Li"
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Sun Y, Li X. (2022) Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states. Nature Cardiovascular Research. 1: 238-245
Chen H, Qi X, Faulkner RA, et al. (2022) Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain. Nature Communications. 13: 4273
Long T, Debler EW, Li X. (2022) Structural enzymology of cholesterol biosynthesis and storage. Current Opinion in Structural Biology. 74: 102369
Long T, Liu Y, Li X. (2021) Molecular structures of human ACAT2 disclose mechanism for selective inhibition. Structure (London, England : 1993)
Qi X, Friedberg L, De Bose-Boyd R, et al. (2020) Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling. Nature Chemical Biology
Wang R, Long T, Hassan A, et al. (2020) Cryo-EM structures of intact V-ATPase from bovine brain. Nature Communications. 11: 3921
Chen H, Liu Y, Li X. (2020) Structure of human Dispatched-1 provides insights into Hedgehog ligand biogenesis. Life Science Alliance. 3
Long T, Sun Y, Hassan A, et al. (2020) Structure of nevanimibe-bound tetrameric human ACAT1. Nature. 581: 339-343
Qi X, Li X. (2020) Mechanistic Insights into the Generation and Transduction of Hedgehog Signaling. Trends in Biochemical Sciences. 45: 397-410
Long T, Qi X, Hassan A, et al. (2020) Structural basis for itraconazole-mediated NPC1 inhibition. Nature Communications. 11: 152
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