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Xiaochun Li

Affiliations: 
2017- Molecular Genetics University of Texas Southwestern Medical Center, Dallas, TX, United States 
Area:
Structural Biology
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"Xiaochun Li"
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Parents

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Yigong Shi grad student 2008-2012 Tsinghua University
Günter Blobel post-doc 2012-2017 Rockefeller

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Publications

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Chen H, Qi X, Faulkner RA, et al. (2022) Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain. Nature Communications. 13: 4273
Long T, Debler EW, Li X. (2022) Structural enzymology of cholesterol biosynthesis and storage. Current Opinion in Structural Biology. 74: 102369
Qi X, Friedberg L, De Bose-Boyd R, et al. (2020) Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling. Nature Chemical Biology
Wang R, Long T, Hassan A, et al. (2020) Cryo-EM structures of intact V-ATPase from bovine brain. Nature Communications. 11: 3921
Long T, Sun Y, Hassan A, et al. (2020) Structure of nevanimibe-bound tetrameric human ACAT1. Nature. 581: 339-343
Long T, Qi X, Hassan A, et al. (2020) Structural basis for itraconazole-mediated NPC1 inhibition. Nature Communications. 11: 152
Long T, Hassan A, Thompson BM, et al. (2019) Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition. Nature Communications. 10: 2452
Fine M, Schmiege P, Li X. (2018) Structural basis for PtdInsP-mediated human TRPML1 regulation. Nature Communications. 9: 4192
Qi X, Schmiege P, Coutavas E, et al. (2018) Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex. Science (New York, N.Y.)
Qi X, Schmiege P, Coutavas E, et al. (2018) Structures of human Patched and its complex with native palmitoylated sonic hedgehog. Nature
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