R. Scott Lokey
Affiliations: | Chemistry & Biochemistry | University of California, Santa Cruz, Santa Cruz, CA, United States |
Area:
drug discoveryWebsite:
http://www.chemistry.ucsc.edu/faculty/singleton.php?&singleton=true&cruz_id=slokeyGoogle:
"R. Scott Lokey"Bio:
http://lokey.chemistry.ucsc.edu/Index.html
http://www1.ucsc.edu/currents/02-03/10-07/newfac.html
Mean distance: 8.37 | S | N | B | C | P |
Parents
Sign in to add mentor| Brent L. Iverson | grad student | 1997 | UT Austin | |
| (Aedamers: A Synthetic Approach to Higher Order Structure) | ||||
| Timothy J. Mitchison | post-doc | 2002 | Harvard Medical School | |
Children
Sign in to add trainee| Grant Koch | grad student | UC Santa Cruz | |
| Rushia Turner | grad student | 2011 | UC Santa Cruz |
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Publications
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| Faris JH, Adaligil E, Popovych N, et al. (2024) Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation. Journal of the American Chemical Society |
| Zhang P, Koch G, Zhang Y, et al. (2023) DNA-Compatible Conditions for the Formation of -Methyl Peptide Bonds. Acs Omega. 8: 23477-23483 |
| van Hoorebeke C, Yang K, Mussetter SJ, et al. (2022) Reevaluation of a Bicyclic Pyrazoline as a Selective 15-Lipoxygenase V-Type Activator Possessing Fatty Acid Specificity. Acs Omega. 7: 43169-43179 |
| Taechalertpaisarn J, Ono S, Okada O, et al. (2022) A New Amino Acid for Improving Permeability and Solubility in Macrocyclic Peptides through Side Chain-to-Backbone Hydrogen Bonding. Journal of Medicinal Chemistry |
| Klein VG, Bray WM, Wang HY, et al. (2021) Identifying the Cellular Target of Cordyheptapeptide A and Synthetic Derivatives. Acs Chemical Biology |
| Kelly CN, Townsend CE, Jain AN, et al. (2020) Geometrically Diverse Lariat Peptide Scaffolds Reveal an Untapped Chemical Space of High Membrane Permeability. Journal of the American Chemical Society |
| Furukawa A, Schwochert J, Pye CR, et al. (2020) Drug-like properties in macrocycles above MW 1000: Backbone rigidity vs. side-chain lipophilicity. Angewandte Chemie (International Ed. in English) |
| Nguyen QNN, Schwochert J, Tantillo DJ, et al. (2018) Using H and C NMR chemical shifts to determine cyclic peptide conformations: a combined molecular dynamics and quantum mechanics approach. Physical Chemistry Chemical Physics : Pccp |
| Townsend C, Furukawa A, Schwochert J, et al. (2018) CycLS: Accurate, whole-library sequencing of cyclic peptides using tandem mass spectrometry. Bioorganic & Medicinal Chemistry |
| Boehm M, Beaumont K, Jones RM, et al. (2017) Discovery of potent and orally bioavailable macrocyclic peptide-peptoid hybrid CXCR7 modulators. Journal of Medicinal Chemistry |