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Jamie B. Spangler

Affiliations: 
2011-2017 Stanford University, Palo Alto, CA 
 2017- Chemical & Biomolecular Engineering Johns Hopkins University, Baltimore, MD 
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K. Dane Wittrup grad student 2011 MIT
K. Christopher Garcia post-doc 2011-2017 Stanford

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Yang H, Karl MN, Wang W, et al. (2022) Engineered bispecific antibodies targeting the interleukin-6 and -8 receptors potently inhibit cancer cell migration and tumor metastasis. Molecular Therapy : the Journal of the American Society of Gene Therapy
Bernstein ZJ, Spangler JB. (2021) Insights into the anticancer mechanisms of interleukin-15 from engineered cytokine therapies. The Journal of Clinical Investigation. 131
Glassman CR, Mathiharan YK, Jude KM, et al. (2021) Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells. Cell. 184: 983-999.e24
VanDyke D, Wang W, Spangler JB. (2020) Innovative synthetic signaling technologies for immunotherapy Current Opinion in Biomedical Engineering. 16: 1-8
Yang H, Kureshi R, Spangler JB. (2019) Structural Basis for Signaling Through Shared Common γ Chain Cytokines. Advances in Experimental Medicine and Biology. 1172: 1-19
Spangler JB, Moraga I, Jude KM, et al. (2019) A strategy for the selection of monovalent antibodies that span protein dimer interfaces. The Journal of Biological Chemistry
Leonard EK, Leff MI, Spangler JB. (2019) Weaponizing T-cell receptors through molecular engineering. The Journal of Biological Chemistry. 294: 5805-5806
Krohl PJ, Ludwig SD, Spangler JB. (2019) Emerging technologies in protein interface engineering for biomedical applications. Current Opinion in Biotechnology. 60: 82-88
Silva DA, Yu S, Ulge UY, et al. (2019) De novo design of potent and selective mimics of IL-2 and IL-15. Nature. 565: 186-191
Spangler JB, Trotta E, Tomala J, et al. (2018) Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy. Journal of Immunology (Baltimore, Md. : 1950)
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