Jamie B. Spangler

Affiliations: 
2011-2017 Stanford University, Palo Alto, CA 
 2017- Chemical & Biomolecular Engineering Johns Hopkins University, Baltimore, MD 
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"Jamie Spangler"
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Publications

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Tomala J, Cao SD, Spangler JB. (2024) Engineering Anticytokine Antibodies for Immune Modulation. Journal of Immunology (Baltimore, Md. : 1950). 212: 225-234
Ray CM, Yang H, Spangler JB, et al. (2023) Mechanistic computational modeling of monospecific and bispecific antibodies targeting interleukin-6/8 receptors. Biorxiv : the Preprint Server For Biology
Tomasovic LM, Liu K, VanDyke D, et al. (2023) Molecular Engineering of Interleukin-2 for Enhanced Therapeutic Activity in Autoimmune Diseases. Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Silver AB, Tzeng SY, Lager M, et al. (2023) An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2. Cell Reports. Medicine. 4: 101289
Kishimoto TK, Fournier M, Michaud A, et al. (2023) Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease. Journal of Autoimmunity. 140: 103125
Sun H, Lee HS, Kim SH, et al. (2023) IL-2 can signal via chemokine receptors to promote regulatory T cells' suppressive function. Cell Reports. 42: 112996
Bernstein ZJ, Shenoy A, Chen A, et al. (2023) Engineering the IL-4/IL-13 axis for targeted immune modulation. Immunological Reviews
Leonard EK, Tomala J, Gould JR, et al. (2023) Engineered cytokine/antibody fusion proteins improve delivery of IL-2 to pro-inflammatory cells and promote antitumor activity. Biorxiv : the Preprint Server For Biology
Deckers J, Anbergen T, Hokke AM, et al. (2023) Engineering cytokine therapeutics. Nature Reviews Bioengineering. 1: 286-303
Yang H, Ulge UY, Quijano-Rubio A, et al. (2023) Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds. Nature Chemical Biology
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