Jamie B. Spangler
Affiliations: | 2011-2017 | Stanford University, Palo Alto, CA | |
2017- | Chemical & Biomolecular Engineering | Johns Hopkins University, Baltimore, MD |
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Parents
Sign in to add mentorK. Dane Wittrup | grad student | 2011 | MIT |
K. Christopher Garcia | post-doc | 2011-2017 | Stanford |
Children
Sign in to add traineeBunyarit Meksiriporn | post-doc | Whiting School of Engineer, Johns Hopkins University (E-Tree) |
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Publications
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Tomala J, Cao SD, Spangler JB. (2024) Engineering Anticytokine Antibodies for Immune Modulation. Journal of Immunology (Baltimore, Md. : 1950). 212: 225-234 |
Ray CM, Yang H, Spangler JB, et al. (2023) Mechanistic computational modeling of monospecific and bispecific antibodies targeting interleukin-6/8 receptors. Biorxiv : the Preprint Server For Biology |
Tomasovic LM, Liu K, VanDyke D, et al. (2023) Molecular Engineering of Interleukin-2 for Enhanced Therapeutic Activity in Autoimmune Diseases. Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy |
Silver AB, Tzeng SY, Lager M, et al. (2023) An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2. Cell Reports. Medicine. 4: 101289 |
Kishimoto TK, Fournier M, Michaud A, et al. (2023) Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease. Journal of Autoimmunity. 140: 103125 |
Sun H, Lee HS, Kim SH, et al. (2023) IL-2 can signal via chemokine receptors to promote regulatory T cells' suppressive function. Cell Reports. 42: 112996 |
Bernstein ZJ, Shenoy A, Chen A, et al. (2023) Engineering the IL-4/IL-13 axis for targeted immune modulation. Immunological Reviews |
Leonard EK, Tomala J, Gould JR, et al. (2023) Engineered cytokine/antibody fusion proteins improve delivery of IL-2 to pro-inflammatory cells and promote antitumor activity. Biorxiv : the Preprint Server For Biology |
Deckers J, Anbergen T, Hokke AM, et al. (2023) Engineering cytokine therapeutics. Nature Reviews Bioengineering. 1: 286-303 |
Yang H, Ulge UY, Quijano-Rubio A, et al. (2023) Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds. Nature Chemical Biology |