Alessio Ciulli
Affiliations: | University of Dundee, Dundee, Scotland, United Kingdom |
Area:
chemical biology, biochemistry, structural biology, PROTACs, targeted protein degradation, fragment-based drug designGoogle:
"Alessio Ciulli"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Ivano Bertini | research assistant | 2000-2002 | University of Florence | |
| Christopher Abell | grad student | 2002-2006 | University of Cambridge, United Kingdom | |
| (Gates Cambridge Scholar, BBSRC CASE with Astex Therapeutics) | ||||
| Christopher Abell | post-doc | 2006-2009 | University of Cambridge, United Kingdom | |
| (College Junior Research Fellow) | ||||
| Tom Blundell | post-doc | 2006-2009 | University of Cambridge, United Kingdom (Computational Biology Tree) | |
| (College Junior Research Fellow) | ||||
| Craig M. Crews | post-doc | 2009-2009 | Yale | |
| (HFSP Visiting Fellow) | ||||
Children
Sign in to add trainee| Emil Bulatov | grad student | 2010-2014 | University of Dundee |
| Fleur M. Ferguson | grad student | 2010-2014 | University of Cambridge, United Kingdom |
| Charlotte Crowe | grad student | 2020-2024 | University of Dundee |
| Dylan M. Lynch | post-doc | 2022- | University of Dundee |
| Matthias Baud | post-doc | 2011-2013 | University of Dundee |
| Carles Galdeano | post-doc | 2012-2015 | University of Dundee |
| Morgan Gadd | post-doc | 2013-2016 | University of Dundee |
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Publications
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| Ramachandran S, Makukhin N, Haubrich K, et al. (2023) Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. Nature Communications. 14: 6345 |
| Vu LP, Diehl CJ, Casement R, et al. (2023) Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers. Journal of Medicinal Chemistry. 66: 12776-12811 |
| Liu X, Ciulli A. (2023) Proximity-Based Modalities for Biology and Medicine. Acs Central Science. 9: 1269-1284 |
| Haubrich K, Spiteri VA, Farnaby W, et al. (2023) Breaking free from the crystal lattice: Structural biology in solution to study protein degraders. Current Opinion in Structural Biology. 79: 102534 |
| Wijaya AJ, Farnaby W, Ciulli A. (2023) Crystallization of VHL-based PROTAC-induced ternary complexes. Methods in Enzymology. 681: 241-263 |
| Kofink C, Trainor N, Mair B, et al. (2022) A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nature Communications. 13: 5969 |
| Liu X, Kalogeropulou AF, Domingos S, et al. (2022) Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2. Journal of the American Chemical Society |
| Diehl CJ, Ciulli A. (2022) Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders. Chemical Society Reviews |
| Grohmann C, Magtoto CM, Walker JR, et al. (2022) Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms. Nature Communications. 13: 2073 |
| Cowan AD, Ciulli A. (2022) Driving E3 Ligase Substrate Specificity for Targeted Protein Degradation: Lessons from Nature and the Laboratory. Annual Review of Biochemistry |