Carles Galdeano
Affiliations: | 2012-2015 | School of Life Sciences | University of Dundee, Dundee, Scotland, United Kingdom |
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| Griñán-Ferré C, Codony S, Pujol E, et al. (2020) Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics |
| Estarellas C, Scaffidi S, Saladino G, et al. (2019) Modulating Ligand Dissociation through Methyl Isomerism in Accessory Sites: Binding of Retinol to Cellular Carriers. Journal of Physical Chemistry Letters. 10: 7333-7339 |
| Galdeano C, Coquelle N, Cieslikiewicz-Bouet M, et al. (2018) Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis. Molecules (Basel, Switzerland). 23 |
| Soares P, Gadd MS, Frost J, et al. (2017) Group-based optimization of potent and cell-active inhibitors of the von Hippel-Lindau (VHL) E3 ubiquitin ligase: structure-activity relationships leading to the chemical probe (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298). Journal of Medicinal Chemistry |
| Galdeano C. (2017) Drugging the undruggable: targeting challenging E3 ligases for personalized medicine. Future Medicinal Chemistry. 9: 347-350 |
| Frost J, Galdeano C, Soares P, et al. (2016) Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nature Communications. 7: 13312 |
| Galdeano C, Ciulli A. (2016) Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology. Future Medicinal Chemistry |
| Sola I, Castellà S, Viayna E, et al. (2015) Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity. Bioorganic & Medicinal Chemistry |
| Galdeano C, Gadd MS, Soares P, et al. (2014) Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities. Journal of Medicinal Chemistry. 57: 8657-63 |
| Pérez-Areales FJ, Di Pietro O, Espargaró A, et al. (2014) Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties. Bioorganic & Medicinal Chemistry. 22: 5298-307 |