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Derek Bates Lowe

Affiliations: 
Vertex Pharmaceuticals, Boston, MA, United States 
 Novartis, Basel, Basel-Stadt, France 
Area:
Medicinal chemistry
Website:
https://blogs.sciencemag.org/pipeline/
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"Derek Lowe"
Bio:

https://en.wikipedia.org/wiki/Derek_Lowe_(chemist)
https://www.google.com/books/edition/Dissertation_Abstracts_International/yI8vAQAAIAAJ?hl=en&gbpv=1&bsq=rosaramicin
https://blogs.sciencemag.org/pipeline/archives/2010/10/28/shine_a_light
https://blogs.sciencemag.org/pipeline/archives/2009/12/15/manfred_christl_rides_again_bonus_idiotic_lab_accident_too

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Parents

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Ned A. Porter research assistant 1983 Duke
Bertram O. Fraser-Reid grad student 1988 Duke
 (Ph.D: "A carbohydrate-based approach to rosaramicin aglycon")
Bernd Giese post-doc 1988-1989 TU Darmstadt

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Publications

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Come JH, Collier PN, Henderson JA, et al. (2018) Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ Inhibitors (PI3Kγ) with Potential for the Treatment of Multiple Sclerosis (MS). Journal of Medicinal Chemistry
Lowe DB. (2018) Introducing Biochemistry to Bedside. Biochemistry. 57: 469
Lowe DB. (2014) Drug discovery: Combichem all over again. Nature Chemistry. 6: 851-2
Lowe DB. (2012) Nowhere to go but up: the return of medicinal chemistry. Acs Medicinal Chemistry Letters. 3: 3-4
Rudolph J, Esler WP, O'connor S, et al. (2007) Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity. Journal of Medicinal Chemistry. 50: 5202-16
Wood J, Bagi CM, Akuche C, et al. (2006) 4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate. Bioorganic & Medicinal Chemistry Letters. 16: 4965-8
Lowe DB, Bifulco N, Bullock WH, et al. (2006) Substituted indanylacetic acids as PPAR-alpha-gamma activators. Bioorganic & Medicinal Chemistry Letters. 16: 297-301
Claus TH, Lowe DB, Liang Y, et al. (2005) Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose. The Journal of Pharmacology and Experimental Therapeutics. 315: 1396-402
Lowe DB, Magnuson S, Qi N, et al. (2004) In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase. Bioorganic & Medicinal Chemistry Letters. 14: 3155-9
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