Matthias Schiedel, PhD

Affiliations: 
Pharmacy University of Erlangen, Erlangen, Bayern, Germany 
Area:
Medicinal Chemistry
Website:
https://www.chemie.nat.fau.de/person/matthias-schiedel/
Google:
"Matthias Schiedel"
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Publications

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Laurin CMC, Bluck JP, Chan AKN, et al. (2020) Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of . Acs Infectious Diseases
Schiedel M, Lehotzky A, Szunyogh S, et al. (2020) HaloTag-targeted Sirtuin rearranging ligand (SirReal) for the development of proteolysis targeting chimeras (PROTACs) against the lysine deacetylase Sirtuin 2 (Sirt2). Chembiochem : a European Journal of Chemical Biology
Schiedel M, Daub H, Itzen A, et al. (2020) Front Cover: Validation of the Slow Off‐Kinetics of Sirtuin‐Rearranging Ligands (SirReals) by Means of Label‐Free Electrically Switchable Nanolever Technology (ChemBioChem 8/2020) Chembiochem. 21: 1050-1050
Schiedel M, Daub H, Itzen A, et al. (2019) Validation of slow off-kinetics of Sirtuin Rearranging Ligands (SirReals) by means of the label-free electrically switchable nanolever technology. Chembiochem : a European Journal of Chemical Biology
Schiedel M, Moroglu M, Ascough DMH, et al. (2019) Chemical epigenetics: the impact of chemical- and chemical biology techniques on bromodomain target validation. Angewandte Chemie (International Ed. in English)
Schiedel M, Conway SJ. (2018) Small molecules as tools to study the chemical epigenetics of lysine acetylation. Current Opinion in Chemical Biology. 45: 166-178
Robaa D, Monaldi D, Wössner N, et al. (2018) Opening the Selectivity Pocket in the Human Lysine Deacetylase Sirtuin2 - New Opportunities, New Questions. Chemical Record (New York, N.Y.)
Jennings LE, Schiedel M, Hewings DS, et al. (2018) BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability. Bioorganic & Medicinal Chemistry
Swyter S, Schiedel M, Monaldi D, et al. (2018) New chemical tools for probing activity and inhibition of the NAD-dependent lysine deacylase sirtuin 2. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 373
Schiedel M, Fallarero A, Luise C, et al. (2017) Synthesis and biological evaluation of 8-hydroxy-2,7-naphthyridin-2-ium salts as novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Medchemcomm. 8: 465-470
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