Giorgio Lagna

University of California, San Francisco, San Francisco, CA 
RNA processing, transcriptional regulation, smooth muscle biology, vertebrate development
"Giorgio Lagna"
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Ali Brivanlou post-doc (Neurotree)
Robert Roeder post-doc
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Hata A, Lagna G. (2019) Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia. Current Opinion in Hematology
Jiang X, Wooderchak-Donahue WL, McDonald J, et al. (2018) Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia. Science Signaling. 11
Jiang X, Hawkins JS, Lee J, et al. (2017) Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice. Nature Communications. 8: 128
Kashima R, Redmond PL, Ghatpande P, et al. (2017) Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome. Science Signaling. 10
Kashima R, Roy S, Ascano M, et al. (2016) Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome. Science Signaling. 9: ra58
Chang J, Davis-Dusenbery BN, Kashima R, et al. (2013) Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress Embo Journal. 32: 3192-3205
Kang H, Louie J, Weisman A, et al. (2012) Inhibition of microRNA-302 (miR-302) by Bone Morphogenetic Protein 4 (BMP4) facilitates the BMP signaling pathway Journal of Biological Chemistry. 287: 38656-38664
Wang D, Prakash J, Nguyen P, et al. (2012) Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A. The Journal of Biological Chemistry. 287: 28067-77
Kang H, Davis-Dusenbery BN, Nguyen PH, et al. (2012) Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. The Journal of Biological Chemistry. 287: 3976-86
Wu C, So J, Davis-Dusenbery BN, et al. (2011) Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2. Molecular and Cellular Biology. 31: 4760-74
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