Sarah Ellen O'Connor

2003-2011 Chemistry Massachusetts Institute of Technology, Cambridge, MA, United States 
 2011- Biological Chemistry John Innes Center 
Biosynthesis and engineering of plant and plant-pathogen natural products
"Sarah E. O'Connor"

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David G. Lynn research assistant 1991-1995 Chicago
Barbara Imperiali grad student 1995-2000 MIT
 (Conformational Effects of Asparagine-Linked Glycosylation.)
Christopher T. Walsh post-doc 2001-2003 Harvard


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Nancy Yerkes Greenland grad student 2010 MIT
M Carmen Galan post-doc MIT
Justin John Maresh post-doc 2004-2008 MIT
Fionn O'Hara post-doc 2013-2014 John Innes Center
Evangelos Tatsis post-doc 2013-2017 John Innes Centre
Jakob Franke post-doc 2015-2017
Thu Thuy T Dang post-doc 2015-2018 John Innes Center
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Dang TT, Franke J, Carqueijeiro IST, et al. (2018) Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes. Nature Chemical Biology
Caputi L, Franke J, Farrow SC, et al. (2018) Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle. Science (New York, N.Y.)
Stavrinides A, Tatsis E, Dang TT, et al. (2018) Discovery of a short chain dehydrogenase from Catharanthus roseus that produces a novel monoterpene indole alkaloid. Chembiochem : a European Journal of Chemical Biology
Tatsis EC, Carqueijeiro I, Dugé de Bernonville T, et al. (2017) A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate. Nature Communications. 8: 316
Dang TT, Franke J, Tatsis EC, et al. (2017) Dual catalytic activity of a cytochrome P450 controls bifurcation at a metabolic branch point of alkaloid biosynthesis in Rauwolfia serpentina. Angewandte Chemie (International Ed. in English)
Stavrinides A, Tatsis EC, Caputi L, et al. (2016) Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity. Nature Communications. 7: 12116
Tatsis EC, O'Connor SE. (2016) New developments in engineering plant metabolic pathways. Current Opinion in Biotechnology. 42: 126-132
Kries H, Caputi L, Stevenson CE, et al. (2015) Structural determinants of reductive terpene cyclization in iridoid biosynthesis. Nature Chemical Biology
O'Connor SE. (2015) Engineering of Secondary Metabolism. Annual Review of Genetics
O'Connor SE. (2015) PLANT BIOCHEMISTRY. Fighting cancer while saving the mayapple. Science (New York, N.Y.). 349: 1167-8
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