Simon J. Boulton
Affiliations: | Cancer Research UK - London Research Institute |
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Parents
Sign in to add mentor| Stephen P. Jackson | grad student | 1994-1998 | (Neurotree) |
| Marc Vidal | post-doc | 1998-2002 | Harvard Medical School (Neurotree) |
Children
Sign in to add trainee| Dragana Ahel | post-doc | 2004-2009 | Cancer Research UK - London Research Institute |
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Publications
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| Grande D, Rajendra E, Mason B, et al. (2024) Assessment of DNA Double Strand Break Repair Activity Using High-throughput and Quantitative Luminescence-based Reporter Assays. Journal of Visualized Experiments : Jove |
| Rajendra E, Grande D, Mason B, et al. (2023) Quantitative, titratable and high-throughput reporter assays to measure DNA double strand break repair activity in cells. Nucleic Acids Research |
| Newton MD, Losito M, Smith QM, et al. (2023) Negative DNA supercoiling induces genome-wide Cas9 off-target activity. Molecular Cell. 83: 3533-3545.e5 |
| Belan O, Greenhough L, Kuhlen L, et al. (2023) Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein. Molecular Cell |
| Greenhough LA, Liang CC, Belan O, et al. (2023) Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor. Nature |
| Fleury H, MacEachern MK, Stiefel CM, et al. (2023) The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining. Molecular Cell |
| Schimmel J, Muñoz-Subirana N, Kool H, et al. (2023) Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways. Cell Reports. 42: 112019 |
| Belan O, Sebald M, Adamowicz M, et al. (2022) POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells. Molecular Cell |
| Borel V, Boeing S, Van Wietmarschen N, et al. (2022) Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis. Cell Reports. 39: 110871 |
| Bayley R, Borel V, Moss RJ, et al. (2022) H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ. Molecular Cell |