Simon J. Boulton

Cancer Research UK - London Research Institute 
"Simon Boulton"
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Stephen P. Jackson grad student 1994-1998 (Neurotree)
Marc Vidal post-doc 1998-2002 Harvard Medical School (Neurotree)
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Newton MD, Losito M, Smith QM, et al. (2023) Negative DNA supercoiling induces genome-wide Cas9 off-target activity. Molecular Cell. 83: 3533-3545.e5
Belan O, Greenhough L, Kuhlen L, et al. (2023) Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein. Molecular Cell
Greenhough LA, Liang CC, Belan O, et al. (2023) Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor. Nature
Fleury H, MacEachern MK, Stiefel CM, et al. (2023) The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining. Molecular Cell
Schimmel J, Muñoz-Subirana N, Kool H, et al. (2023) Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways. Cell Reports. 42: 112019
Rodriguez-Berriguete G, Ranzani M, Prevo R, et al. (2023) Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research
Belan O, Sebald M, Adamowicz M, et al. (2022) POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells. Molecular Cell
Borel V, Boeing S, Van Wietmarschen N, et al. (2022) Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis. Cell Reports. 39: 110871
Bayley R, Borel V, Moss RJ, et al. (2022) H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ. Molecular Cell
Silva N, Castellano-Pozo M, Matsuzaki K, et al. (2022) Proline-specific aminopeptidase P prevents replication-associated genome instability. Plos Genetics. 18: e1010025
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