Benedikt Kessler
Affiliations: | Nuffield Department of Medicine | Oxford University UK |
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| Mathea S, Salah E, Tallant C, et al. (2021) Conformational plasticity of the ULK3 kinase domain. The Biochemical Journal |
| Ward JA, Pinto-Fernandez A, Cornelissen L, et al. (2020) Re-evaluating the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: a paradigmatic example of unspecific protein crosslinking with Michael acceptor motif-containing drugs. Journal of Medicinal Chemistry |
| D'Ascenzio M, Pugh KM, Konietzny R, et al. (2018) An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains. Angewandte Chemie (International Ed. in English) |
| Vazquez-Rodriguez S, Wright M, Rogers CM, et al. (2018) Design, Synthesis and Characterization of Covalent KDM5 Inhibitors. Angewandte Chemie (International Ed. in English) |
| Turnbull AP, Ioannidis S, Krajewski WW, et al. (2017) Molecular basis of USP7 inhibition by selective small-molecule inhibitors. Nature |
| Schuller M, Riedel K, Gibbs-Seymour I, et al. (2017) Discovery of a selective allosteric inhibitor targeting macrodomain 2 of poly-adenosine-diphosphate-ribose polymerases 14. Acs Chemical Biology |
| Gerken P, Wolstenhulme J, Tumber A, et al. (2017) Discovery of a highly selective cell-active inhibitor of KDM2/7. Angewandte Chemie (International Ed. in English) |
| Nicholson J, Jevons S, Groselj B, et al. (2017) E3 ligase cIAP2 mediates downregulation of MRE11 and radiosensitization in response to HDAC inhibition in bladder cancer. Cancer Research |
| Olzscha H, Fedorov O, Kessler BM, et al. (2016) CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation. Cell Chemical Biology |
| Lu M, Breyssens H, Salter V, et al. (2016) Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP. Cancer Cell. 30: 822-823 |