Benedikt Kessler

Nuffield Department of Medicine Oxford University UK 
"Benedikt Kessler"
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Mathea S, Salah E, Tallant C, et al. (2021) Conformational plasticity of the ULK3 kinase domain. The Biochemical Journal
Ward JA, Pinto-Fernandez A, Cornelissen L, et al. (2020) Re-evaluating the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: a paradigmatic example of unspecific protein crosslinking with Michael acceptor motif-containing drugs. Journal of Medicinal Chemistry
D'Ascenzio M, Pugh KM, Konietzny R, et al. (2018) An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains. Angewandte Chemie (International Ed. in English)
Vazquez-Rodriguez S, Wright M, Rogers CM, et al. (2018) Design, Synthesis and Characterization of Covalent KDM5 Inhibitors. Angewandte Chemie (International Ed. in English)
Turnbull AP, Ioannidis S, Krajewski WW, et al. (2017) Molecular basis of USP7 inhibition by selective small-molecule inhibitors. Nature
Schuller M, Riedel K, Gibbs-Seymour I, et al. (2017) Discovery of a selective allosteric inhibitor targeting macrodomain 2 of poly-adenosine-diphosphate-ribose polymerases 14. Acs Chemical Biology
Gerken P, Wolstenhulme J, Tumber A, et al. (2017) Discovery of a highly selective cell-active inhibitor of KDM2/7. Angewandte Chemie (International Ed. in English)
Nicholson J, Jevons S, Groselj B, et al. (2017) E3 ligase cIAP2 mediates downregulation of MRE11 and radiosensitization in response to HDAC inhibition in bladder cancer. Cancer Research
Olzscha H, Fedorov O, Kessler BM, et al. (2016) CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation. Cell Chemical Biology
Lu M, Breyssens H, Salter V, et al. (2016) Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP. Cancer Cell. 30: 822-823
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