Olga Amosova, Ph.D.

Armonica Technologies, Inc. 
biochemistry, biophysics, molecular biology
"Olga Amosova"
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Fresco JR, Amosova O. (2017) Site-Specific Self-Catalyzed DNA Depurination: A Biological Mechanism That Leads to Mutations and Creates Sequence Diversity. Annual Review of Biochemistry. 86: 461-484
Amosova O, Alvarez-Dominguez JR, Fresco JR. (2015) Why the DNA self-depurination mechanism operates in HB-β but not in β-globin paralogs HB-δ, HB-ɛ1, HB-γ1 and HB-γ2. Mutation Research. 778: 11-17
Alvarez-Dominguez JR, Amosova O, Fresco JR. (2013) Self-catalytic DNA depurination underlies human β-globin gene mutations at codon 6 that cause anemias and thalassemias. The Journal of Biological Chemistry. 288: 11581-9
Amosova O, Smith A, Fresco JR. (2011) The consensus sequence for self-catalyzed site-specific G residue depurination in DNA. The Journal of Biological Chemistry. 286: 36316-21
Amosova O, Kumar V, Deutsch A, et al. (2011) Self-catalyzed site-specific depurination of G residues mediated by cruciform extrusion in closed circular DNA plasmids. The Journal of Biological Chemistry. 286: 36322-30
Varganov Y, Amosova O, Fresco JR. (2007) Third strand-mediated psoralen-induced correction of the sickle cell mutation on a plasmid transfected into COS-7 cells. Gene Therapy. 14: 173-9
Amosova O, Coulter R, Fresco JR. (2006) Self-catalyzed site-specific depurination of guanine residues within gene sequences. Proceedings of the National Academy of Sciences of the United States of America. 103: 4392-7
Broitman SL, Amosova O, Fresco JR. (2003) Repairing the Sickle Cell mutation. III. Effect of irradiation wavelength on the specificity and type of photoproduct formed by a 3'-terminal psoralen on a third strand directed to the mutant base pair. Nucleic Acids Research. 31: 4682-8
Amosova O, Broitman SL, Fresco JR. (2003) Repairing the Sickle Cell mutation. II. Effect of psoralen linker length on specificity of formation and yield of third strand-directed photoproducts with the mutant target sequence. Nucleic Acids Research. 31: 4673-81
Fabregat I, Koch KS, Aoki T, et al. (2001) Functional pleiotropy of an intramolecular triplex-forming fragment from the 3'-UTR of the rat Pigr gene. Physiological Genomics. 5: 53-65
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