Scott T. Lefurgy, Ph.D.

Affiliations: 
Chemistry Hofstra University, Hempstead, NY, United States 
Area:
Mechanistic Enzymology
Website:
http://www.hofstra.edu/Faculty/fac_profiles.cfm?id=2825
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"Scott Lefurgy"
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Parents

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Charles F. Yocum research assistant 1997-1999 University of Michigan
Virginia W. Cornish grad student 2001-2007 Columbia
 (Complementation strategies applied to drug discovery and enzymology.)
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Publications

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Lefurgy ST, Malashkevich VN, Aguilan JT, et al. (2015) FOX-4 cephamycinase: an analysis of structure and function. Antimicrobial Agents and Chemotherapy
Fernandes P, Aldeborgh H, Carlucci L, et al. (2015) Alteration of substrate specificity of alanine dehydrogenase. Protein Engineering, Design & Selection : Peds. 28: 29-35
Ruble JF, Lefurgy ST, Cornish VW, et al. (2012) Structural analysis of the Asn152Gly mutant of P99 cephalosporinase. Acta Crystallographica. Section D, Biological Crystallography. 68: 1189-93
Lefurgy ST, Leyh TS. (2012) Analytical expressions for the homotropic binding of ligand to protein dimers and trimers Analytical Biochemistry. 421: 433-438
Lefurgy ST, Rodriguez SB, Park CS, et al. (2010) Probing ligand-binding pockets of the mevalonate pathway enzymes from Streptococcus pneumoniae. The Journal of Biological Chemistry. 285: 20654-63
Kudoh T, Park CS, Lefurgy ST, et al. (2010) Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae Bioorganic and Medicinal Chemistry. 18: 1124-1134
Lefurgy ST, de Jong RM, Cornish VW. (2007) Saturation mutagenesis of Asn152 reveals a substrate selectivity switch in P99 cephalosporinase. Protein Science : a Publication of the Protein Society. 16: 2636-46
Lefurgy S, Cornish V. (2006) Chemical Complementation Enzyme Assays: High-Throughput Screening, Genetic Selection and Fingerprinting. 183-219
Lefurgy S, Cornish V. (2004) Finding Cinderella after the ball: A three-hybrid approach to drug target identification Chemistry and Biology. 11: 151-153
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