Muthiah Manoharan
Affiliations: | Alnylam Pharmaceuticals |
Area:
Organic Chemistry, Bioorganic Chemistry, Oligonucleotide Chemistry and RNA Therapeutics,Website:
https://www.umassmed.edu/RNATx/speakers1/muthiah-manoharan/Google:
"Muthiah Manoharan"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Ernest Ludwig Eliel | grad student | 1978-1983 | UNC Chapel Hill |
| John A. Gerlt | post-doc | 1983-1988 | Yale |
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Publications
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| Das RS, Datta D, Brown CR, et al. (2025) Expanding Conjugate Space of RNAi Therapeutics: Ligand at the 3' End of the Antisense Strand Achieves Uncompromised In Vivo Potency and Efficacy and Reveals Interactions with the Argonaute-2 PAZ Domain. Journal of Medicinal Chemistry |
| Datta D, Kumar P, Kundu J, et al. (2024) Improved Metabolic Stability and Silencing Efficacy of siRNAs with Phosphorothioate Linkage-Free, GalNAc-Conjugated Sense Strands Containing Morpholino-LNA Modifications. Organic Letters |
| Datta D, Kumar P, Mandal S, et al. (2024) Conformation matters: siRNAs with antisense strands with 5'-()-vinyl-phosphonate-α-L-LNA elicit stronger RNAi-mediated gene silencing than those with 5'-()-vinyl-phosphonate-LNA. Chemical Communications (Cambridge, England) |
| Aluri KC, Datta D, Waldron S, et al. (2024) Single-Stranded Hairpin Loop RNAs (loopmeRNAs) Potently Induce Gene Silencing through the RNA Interference Pathway. Journal of the American Chemical Society |
| Matsuda S, Bala S, Liao JY, et al. (2023) Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs. Journal of the American Chemical Society |
| Datta D, Theile CS, Wassarman K, et al. (2023) Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex. Chemical Communications (Cambridge, England) |
| Anthiya S, Öztürk SC, Yanik H, et al. (2023) Targeted siRNA lipid nanoparticles for the treatment of KRAS-mutant tumors. Journal of Controlled Release : Official Journal of the Controlled Release Society |
| Egli M, Manoharan M. (2023) Chemistry, structure and function of approved oligonucleotide therapeutics. Nucleic Acids Research |
| Kandasamy P, Mori S, Matsuda S, et al. (2023) Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways. Journal of Medicinal Chemistry |
| Ghosh A, Akabane-Nakata M, Kundu J, et al. (2023) Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers. Organic Letters |