Muthiah Manoharan
Affiliations: | Alnylam Pharmaceuticals |
Area:
Organic Chemistry, Bioorganic Chemistry, Oligonucleotide Chemistry and RNA Therapeutics,Website:
https://www.umassmed.edu/RNATx/speakers1/muthiah-manoharan/Google:
"Muthiah Manoharan"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Ernest Ludwig Eliel | grad student | 1978-1983 | UNC Chapel Hill |
| John A. Gerlt | post-doc | 1983-1988 | Yale |
BETA: Related publications
See more...
Publications
|
You can help our author matching system! If you notice any publications incorrectly attributed to this author, please sign in and mark matches as correct or incorrect. |
| Matsuda S, Bala S, Liao JY, et al. (2023) Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs. Journal of the American Chemical Society |
| Datta D, Theile CS, Wassarman K, et al. (2023) Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex. Chemical Communications (Cambridge, England) |
| Anthiya S, Öztürk SC, Yanik H, et al. (2023) Targeted siRNA lipid nanoparticles for the treatment of KRAS-mutant tumors. Journal of Controlled Release : Official Journal of the Controlled Release Society |
| Egli M, Manoharan M. (2023) Chemistry, structure and function of approved oligonucleotide therapeutics. Nucleic Acids Research |
| Kandasamy P, Mori S, Matsuda S, et al. (2023) Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways. Journal of Medicinal Chemistry |
| Ghosh A, Akabane-Nakata M, Kundu J, et al. (2023) Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers. Organic Letters |
| Egli M, Schlegel MK, Manoharan M. (2023) Acyclic (S)-Glycol Nucleic Acid (S-GNA) Modification of siRNAs Improves the Safety of RNAi Therapeutics While Maintaining Potency. Rna (New York, N.Y.) |
| Clua A, Grijalvo S, Erande N, et al. (2022) Correction: Clua et al. Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes. 2022, , 3944. Molecules (Basel, Switzerland). 28 |
| Engelbeen S, Pasteuning-Vuhman S, Boertje-van der Meulen J, et al. (2022) Efficient Downregulation of in Skeletal Muscle After Systemic Treatment with Conjugated siRNAs in a Mouse Model for Duchenne Muscular Dystrophy. Nucleic Acid Therapeutics |
| Madaoui M, Datta D, Wassarman K, et al. (2022) A Chemical Approach to Introduce 2,6-Diaminopurine and 2-Aminoadenine Conjugates into Oligonucleotides without Need for Protecting Groups. Organic Letters |