John B. Little, M.D.

Affiliations: 
Harvard University, Cambridge, MA, United States 
Website:
http://www.hsph.harvard.edu/john-little/
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Publications

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Wang B, Lim CB, Yan J, et al. (2020) MDMX phosphorylation-dependent p53 downregulation contributes to an immunosuppressive tumor microenvironment. Journal of Molecular Cell Biology
Gong L, Pan X, Abali GK, et al. (2019) Functional interplay between p53 and Δ133p53 in adaptive stress response. Cell Death and Differentiation
Molloy ME, Lewinska M, Williamson AK, et al. (2018) ZBTB7A governs estrogen receptor alpha expression in breast cancer. Journal of Molecular Cell Biology. 10: 273-284
Kuser-Abali G, Gong L, Yan J, et al. (2018) An EZH2-mediated epigenetic mechanism behind p53-dependent tissue sensitivity to DNA damage. Proceedings of the National Academy of Sciences of the United States of America
Gong L, Pan X, Lim CB, et al. (2018) A functional interplay between Δ133p53 and ΔNp63 in promoting glycolytic metabolism to fuel cancer cell proliferation. Oncogene
Nagasawa H, Lin YF, Kato TA, et al. (2017) Coordination of the Ser2056 and Thr2609 Clusters of DNA-PKcs in Regulating Gamma Rays and Extremely Low Fluencies of Alpha-Particle Irradiation to G0/G1 Phase Cells. Radiation Research
de Polo A, Vivekanandan V, Little JB, et al. (2016) MDMX under stress: the MDMX-MDM2 complex as stress signals hub. Translational Cancer Research. 5: 725-732
de Polo A, Luo Z, Gerarduzzi C, et al. (2016) AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX-MDM2 complex. Journal of Molecular Cell Biology
Gerarduzzi C, de Polo A, Liu XS, et al. (2016) Her4 Suppresses p53 Via Targeting the MDMX-MDM2 Complex: Implication of a Novel MDMX Ser314 Phosphosite. The Journal of Biological Chemistry
Qi M, Ganapathy S, Zeng W, et al. (2015) UXT, a novel MDMX-binding protein, promotes glycolysis by mitigating p53-mediated restriction of NF-κB activity. Oncotarget
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