Joseph J. Falke, Ph.D.

Affiliations: 
1987- Chemistry & Biophysics University of Colorado, Boulder, Boulder, CO, United States 
Area:
chemosensory pathways
Website:
http://spot.colorado.edu/~falke/FalkeBio.html
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"Joseph Falke"
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SNBCP

Parents

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Sunney I. Chan grad student 1979-1984 Caltech
 (The behavior and structure of the band 3 anion transport site: A 35Cl and 37Cl NMR study.)
Daniel E. Koshland post-doc 1985-1987 UC Berkeley

Children

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Claire Careaga grad student 1993 CU Boulder
Steve Chervitz grad student 1990-1995 CU Boulder
Steve Drake grad student 1996 CU Boulder
Randal Bass grad student 1998 CU Boulder
Scott Butler grad student 1998 CU Boulder
Joshua Bornhorst grad student 2002 CU Boulder
Susy C. Kohout grad student 2002 CU Boulder (Neurotree)
Nathan Malmberg grad student 2004 CU Boulder
Aaron Miller grad student 2006 CU Boulder
Kyle Landgraf grad student 2009 CU Boulder
Ka Lin Swain grad student 2010 CU Boulder
Pete Slivka grad student 2012 CU Boulder
John Corbin post-doc XOMA Inc
Annette Erbse post-doc CU Boulder
Jefferson Knight post-doc UC Denver
Linda A. Luck post-doc Clarkson University
Eric Nalefski post-doc US Genomics
Olve B. Peersen post-doc Colorado State
Kene N. Piasta post-doc Brandeis
Jefferson D. Knight post-doc 2006-2010 CU Boulder
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Publications

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Hannan JP, Swisher GH, Martyr JG, et al. (2021) HPLC method to resolve, identify and quantify guanine nucleotides bound to recombinant ras GTPase. Analytical Biochemistry. 114338
Swisher GH, Hannan JP, Cordaro NJ, et al. (2021) Ras-Guanine Nucleotide Complexes: A UV Spectral Deconvolution Method to Analyze Protein Concentration, Nucleotide Stoichiometry, and Purity. Analytical Biochemistry. 114066
Buckles TC, Ohashi Y, Tremel S, et al. (2020) Regulation of a Class III PI3K Lipid Kinase (VPS34 Complex II) by the Small G Protein Rab5A: Single Molecule Analysis Reveals a Dual Regulatory Mechanism. Biophysical Journal
Buckles TC, Ziemba BP, Djukovic D, et al. (2020) Rapid exposure of macrophages to drugs resolves four classes of effects on the leading edge sensory pseudopod: Non-perturbing, adaptive, disruptive, and activating. Plos One. 15: e0233012
Gordon MT, Falke JJ. (2020) Direct Detection and Characterization of a Phosphoinositide Dependent Kinase-1 (PDK1) Homodimer on a Target Membrane Surface Via Single Molecule Fluorescence Biophysical Journal. 118
Falke JJ, Ziemba BP, Buckles TC, et al. (2020) Regulatory Mechanisms of Ca2+, Receptor, Ras, and Lipid Signals that Control Actin Polymerization During Cell Migration Biophysical Journal. 118
Swisher GH, Cordaro NJ, Martyr JG, et al. (2020) Binding of Ras to PI3K: Measuring Binding Affinity, and the Effects of Disease-Linked H-Ras Mutations on Affinity Biophysical Journal. 118
Ziemba BP, Falke JJ. (2018) A PKC-MARCKS-PI3K regulatory module links Ca2+ and PIP3 signals at the leading edge of polarized macrophages. Plos One. 13: e0196678
Buckles TC, Ziemba BP, Masson GR, et al. (2017) Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP3 Signaling. Biophysical Journal. 113: 2396-2405
Buckles T, Ziemba B, Burke JE, et al. (2017) Activation of PI3K by Ras: Single Molecule Studies of the Activation Mechanism Biophysical Journal. 112
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