Pathum Weerawarna, Ph.D
Affiliations: | 2022- | Medicine | Indiana University School of Medicine, Indianapolis, IN, United States |
Area:
Bioorganic and Medicinal ChemistryWebsite:
https://medicine.iu.edu/faculty/61382/weerawarna-pathumGoogle:
"Pathum Weerawarna"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| William C. Groutas | grad student | 2011-2016 | Wichita State University |
| Richard B. Silverman | post-doc | 2016-2021 | Northwestern |
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Publications
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| Weerawarna PM. (2024) How Polyproline Type II Conformation at P Residues Influences the Success of Proline-Based Peptidyl Inhibitors Against Coronavirus Main Protease. Biochemistry. 64: 533-546 |
| Dukes AO, Weerawarna PM, Devitt AN, et al. (2024) Synthesis of (2,4)-4-Amino-5-hydroxybicyclo[3.1.1]heptane-2-carboxylic Acid via an Asymmetric Intramolecular Mannich Reaction. The Journal of Organic Chemistry. 89: 9110-9117 |
| Weerawarna PM, Schiefer IT, Soares P, et al. (2023) Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis. Acs Central Science. 10: 87-103 |
| Zhu W, Doubleday PF, Butrin A, et al. (2021) Remarkable and Unexpected Mechanism for ()-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase. Journal of the American Chemical Society |
| Weerawarna PM, Moschitto MJ, Silverman RB. (2021) Theoretical and Mechanistic Validation of Global Kinetic Parameters of the Inactivation of GABA Aminotransferase by OV329 and CPP-115. Acs Chemical Biology |
| Shen S, Doubleday PF, Weerawarna PM, et al. (2020) Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase. Acs Medicinal Chemistry Letters. 11: 1949-1955 |
| Zhu W, Doubleday PF, Catlin DS, et al. (2020) A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid. Journal of the American Chemical Society |
| Galasiti Kankanamalage AC, Weerawarna PM, Rathnayake AD, et al. (2019) Putative Structural Rearrangements Associated with the Interaction of Macrocyclic Inhibitors with Norovirus 3CL Protease. Proteins |
| Juncosa JI, Takaya K, Le HV, et al. (2018) Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction. Journal of the American Chemical Society |
| Galasiti Kankanamalage AC, Kim Y, Rathnayake AD, et al. (2016) Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors. European Journal of Medicinal Chemistry. 126: 502-516 |