Pathum Weerawarna, Ph.D

Affiliations: 
2022- Medicine Indiana University School of Medicine, Indianapolis, IN, United States 
Area:
Bioorganic and Medicinal Chemistry
Website:
https://medicine.iu.edu/faculty/61382/weerawarna-pathum
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"Pathum Weerawarna"
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Publications

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Zhu W, Doubleday PF, Butrin A, et al. (2021) Remarkable and Unexpected Mechanism for ()-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase. Journal of the American Chemical Society
Weerawarna PM, Moschitto MJ, Silverman RB. (2021) Theoretical and Mechanistic Validation of Global Kinetic Parameters of the Inactivation of GABA Aminotransferase by OV329 and CPP-115. Acs Chemical Biology
Shen S, Doubleday PF, Weerawarna PM, et al. (2020) Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase. Acs Medicinal Chemistry Letters. 11: 1949-1955
Zhu W, Doubleday PF, Catlin DS, et al. (2020) A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid. Journal of the American Chemical Society
Galasiti Kankanamalage AC, Weerawarna PM, Rathnayake AD, et al. (2019) Putative Structural Rearrangements Associated with the Interaction of Macrocyclic Inhibitors with Norovirus 3CL Protease. Proteins
Juncosa JI, Takaya K, Le HV, et al. (2018) Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction. Journal of the American Chemical Society
Galasiti Kankanamalage AC, Kim Y, Rathnayake AD, et al. (2016) Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors. European Journal of Medicinal Chemistry. 126: 502-516
Weerawarna PM, Kim Y, Galasiti Kankanamalage AC, et al. (2016) Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies. European Journal of Medicinal Chemistry. 119: 300-318
Galasiti Kankanamalage AC, Weerawarna PM, Kim Y, et al. (2016) Anti-Norovirus Therapeutics: A Patent Review (2010-2015). Expert Opinion On Therapeutic Patents
Damalanka VC, Kim Y, Alliston KR, et al. (2016) Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL Protease. Journal of Medicinal Chemistry
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