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Huda Zahid, Ph.D

Affiliations: 
2017- Chemistry University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
chemical biology, epigenetics
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"Huda Zahid"
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Parents

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William C. Pomerantz grad student 2017-2022 UMN
Christopher M. Hickey research scientist 2022-

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Publications

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Zahid H, Costello JP, Li Y, et al. (2023) Design of Class I/IV Bromodomain-Targeting Degraders for Chromatin Remodeling Complexes. Acs Chemical Biology
Divakaran A, Scholtz CR, Zahid H, et al. (2022) Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader. Acs Medicinal Chemistry Letters. 13: 1621-1627
Kalra P, Zahid H, Ayoub A, et al. (2022) Alternative Mechanisms for DNA Engagement by BET Bromodomain-Containing Proteins. Biochemistry
Cui H, Divakaran A, Hoell ZJ, et al. (2022) A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes. Journal of Medicinal Chemistry
Zahid H, Buchholz CR, Singh M, et al. (2021) New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. Journal of Medicinal Chemistry
Cui H, Carlson AS, Schleiff MA, et al. (2021) 4-Methyl-1,2,3-Triazoles as -Acetyl-Lysine Mimics Afford Potent BET Bromodomain Inhibitors with Improved Selectivity. Journal of Medicinal Chemistry
Zahid H, Olson NM, Pomerantz WCK. (2021) Opportunity knocks for uncovering the new function of an understudied nucleosome remodeling complex member, the bromodomain PHD finger transcription factor, BPTF. Current Opinion in Chemical Biology. 63: 57-67
Pomerantz WCK, Cui H, Divakaran A, et al. (2020) Selective N-terminal BRD4 bromodomain inhibitors by targeting non-conserved residues and structured water displacement. Angewandte Chemie (International Ed. in English)
Ycas PD, Zahid H, Chan A, et al. (2020) New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development. Organic & Biomolecular Chemistry
Kirberger SE, Ycas PD, Johnson JA, et al. (2019) Selectivity, ligand deconstruction, and cellular activity analysis of a BPTF bromodomain inhibitor. Organic & Biomolecular Chemistry
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