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Mini Thomas

Affiliations: 
Quince Therapeutics 
Area:
Biotechnology, Chemistry
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"Mini Thomas"
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Parents

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Santanu Bhattacharya grad student 1996-2001 Indian Institute of Science
 (Senior Scient Quince Therapeutics)
Alexander M. Klibanov post-doc 2002-2007 MIT
 (Senior Scient Quince Therapeutics)

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Publications

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Grant EV, Thomas M, Fortune J, et al. (2012) Enhancement of plasmid DNA immunogenicity with linear polyethylenimine. European Journal of Immunology. 42: 2937-48
Devitt G, Thomas M, Klibanov AM, et al. (2007) Optimized protocol for the large scale production of HIV pseudovirions by transient transfection of HEK293T cells with linear fully deacylated polyethylenimine. Journal of Virological Methods. 146: 298-304
Thomas M, Lu JJ, Chen J, et al. (2007) Non-viral siRNA delivery to the lung. Advanced Drug Delivery Reviews. 59: 124-33
Thomas M, Lu JJ, Zhang C, et al. (2007) Identification of novel superior polycationic vectors for gene delivery by high-throughput synthesis and screening of a combinatorial library. Pharmaceutical Research. 24: 1564-71
Thomas M, Ge Q, Lu JJ, et al. (2005) Polycation-mediated delivery of siRNAs for prophylaxis and treatment of influenza virus infection. Expert Opinion On Biological Therapy. 5: 495-505
Thomas M, Ge Q, Lu JJ, et al. (2005) Cross-linked small polyethylenimines: while still nontoxic, deliver DNA efficiently to mammalian cells in vitro and in vivo. Pharmaceutical Research. 22: 373-80
Thomas M, Lu JJ, Ge Q, et al. (2005) Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung. Proceedings of the National Academy of Sciences of the United States of America. 102: 5679-84
Sharma VK, Thomas M, Klibanov AM. (2005) Mechanistic studies on aggregation of polyethylenimine-DNA complexes and its prevention. Biotechnology and Bioengineering. 90: 614-20
Akinc A, Thomas M, Klibanov AM, et al. (2005) Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis. The Journal of Gene Medicine. 7: 657-63
Thomas M, Klibanov AM. (2003) Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 9138-43
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