Simon J Hedley

1995-2003 Chemistry University of Sheffield, Sheffield, England, United Kingdom 
 2003-2006 Chemistry State University of New York, Buffalo, Buffalo, NY, United States 
 2006-2018 Drug Substance Synthetic Technologies Amgen Inc., Thousand Oaks, CA, United States 
 2020-2021 Drug Substance Arcinova 
 2021- Drug Substance PR&D Quotient Sciences 
Process Chemistry, Organic Synthesis, Catalysis, Crystallisation, Biocatalysis
"Simon Hedley"
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Wurz RP, Pettus LH, Ashton K, et al. (2015) Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors. Acs Medicinal Chemistry Letters. 6: 987-92
Davies HM, Hedley SJ. (2007) Intermolecular reactions of electron-rich heterocycles with copper and rhodium carbenoids. Chemical Society Reviews. 36: 1109-19
Murthy V, Davies HM, Hedley SJ, et al. (2007) Irreversible binding of a novel phenylisothiocyanate tropane analog to monoamine transporters in rat brain. Biochemical Pharmacology. 74: 336-44
Hedley SJ, Ventura DL, Dominiak PM, et al. (2006) Investigation into factors influencing stereoselectivity in the reactions of heterocycles with donor-acceptor-substituted rhodium carbenoids. The Journal of Organic Chemistry. 71: 5349-56
Davies HM, Hedley SJ, Bohall BR. (2005) Asymmetric intermolecular C-H functionalization of benzyl silyl ethers mediated by chiral auxiliary-based aryldiazoacetates and chiral dirhodium catalysts. The Journal of Organic Chemistry. 70: 10737-42
Hedley SJ, Moran WJ, Price DA, et al. (2003) Development of a [3+3] cycloaddition strategy toward functionalized piperidines. The Journal of Organic Chemistry. 68: 4286-92
Hedley SJ, Moran WJ, Prenzel AGHP, et al. (2001) Synthesis of Functionalised Piperidines Through a [3 + 3] Cycloaddition Strategy Synlett. 1596-1598
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