Hongyu Li
Affiliations: | Pharmaceutical Sciences | University of Arkansas for Medical Sciences, United States |
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Cross-listing: Neurotree
Children
Sign in to add traineeBrendan Frett | grad student | UAMS | |
Rajiv Lakkaniga | grad student | Indian Institute of Technology (IIT) - Indian School of Mines (ISM), Dhanbad | |
Xiuqi Wang | grad student | 2018-2023 | UAMS |
Jingwei Shao | post-doc | Chongqing University of Arts and Sciences | |
Yuanxiang Wang | post-doc | Sun Yat-sen University |
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Publications
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Zhang L, Moccia M, Briggs DC, et al. (2022) Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose. Journal of Medicinal Chemistry. 65: 1536-1551 |
Zhang L, Lakkaniga NR, Bharate JB, et al. (2021) Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor. European Journal of Medicinal Chemistry. 225: 113776 |
Kharbanda A, Tran P, Zhang L, et al. (2021) Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology. European Journal of Medicinal Chemistry. 225: 113763 |
Moccia M, Yang D, Lakkaniga NR, et al. (2021) Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases. Scientific Reports. 11: 16103 |
Kharbanda A, Zhang L, Saha D, et al. (2021) Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors. European Journal of Medicinal Chemistry. 223: 113660 |
Yan W, Zhang L, Lv F, et al. (2021) Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation. European Journal of Medicinal Chemistry. 216: 113265 |
Wang J, Cheng P, Pavlyukov MS, et al. (2020) Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. The Journal of Clinical Investigation |
Wang H, Chen Y, Gu X, et al. (2020) Design, synthesis, and structure activity relationship (SAR) studies of novel imidazo[1,2-a] pyridine derivatives as Nek2 inhibitors. Bioorganic & Medicinal Chemistry. 28: 115775 |
Wang J, Cheng P, Pavlyukov MS, et al. (2020) Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2. The Journal of Clinical Investigation. 130: 5027 |
Yan W, Lakkaniga NR, Carlomagno F, et al. (2020) Correction to Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application. Journal of Medicinal Chemistry |