Jonathan B. Spencer, Ph.D.

1994-2008 Chemistry University of Cambridge, Cambridge, England, United Kingdom 
biosynthesis of antibiotics
"Jonathan Spencer"
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Hüttel W, Spencer JB, Leadlay PF. (2014) Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding. Beilstein Journal of Organic Chemistry. 10: 361-8
Dias MV, Huang F, Chirgadze DY, et al. (2010) Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK. The Journal of Biological Chemistry. 285: 22495-504
Tosin M, Betancor L, Stephens E, et al. (2010) Synthetic chain terminators off-load intermediates from a type I polyketide synthase. Chembiochem : a European Journal of Chemical Biology. 11: 539-46
Gaunt MJ, Yu J, Spencer JB. (2010) ChemInform Abstract: Evidence that the Availability of an Allylic Hydrogen Governs the Regioselectivity of the Wacker Oxidation. Cheminform. 33: no-no
Yu J, Spencer JB. (2010) ChemInform Abstract: New Insight into the Mechanism of Catalytic Hydrogenation Allows the Structure of the Key Intermediate in Asymmetric Hydrogenation to be Predicted. Cheminform. 30: no-no
YU J, SPENCER JB. (2010) ChemInform Abstract: Stereoselective Deoxygenation of myo-Inositol Monotosylates with Lithium Triethylborohydride. Cheminform. 27: no-no
Wu HC, Hamid SA, Yu JQ, et al. (2009) Possible origin of electronic effects in Rh(I)-catalyzed enantioselective hydrogenation. Journal of the American Chemical Society. 131: 9604-5
Tosin M, Spiteller D, Spencer JB. (2009) Malonyl carba(dethia)- and malonyl oxa(dethia)-coenzyme A as tools for trapping polyketide intermediates. Chembiochem : a European Journal of Chemical Biology. 10: 1714-23
Smith L, Hong H, Spencer JB, et al. (2008) Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closure. Chembiochem : a European Journal of Chemical Biology. 9: 2967-75
Fan Q, Huang F, Leadlay PF, et al. (2008) The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase. Organic & Biomolecular Chemistry. 6: 3306-14
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