Jonathan B. Spencer, Ph.D.

1994-2008 Chemistry University of Cambridge, Cambridge, England, United Kingdom 
biosynthesis of antibiotics
"Jonathan Spencer"
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Hüttel W, Spencer JB, Leadlay PF. (2014) Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding. Beilstein Journal of Organic Chemistry. 10: 361-8
Dias MV, Huang F, Chirgadze DY, et al. (2010) Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK. The Journal of Biological Chemistry. 285: 22495-504
Tosin M, Betancor L, Stephens E, et al. (2010) Synthetic chain terminators off-load intermediates from a type I polyketide synthase. Chembiochem : a European Journal of Chemical Biology. 11: 539-46
Sandercock AM, Charles EH, Scaife W, et al. (2010) ChemInform Abstract: Biosynthesis of the Di-meta-hydroxyphenylglycine Constituent of the Vancomycin-Group Antibiotic Chloroeremomycin. Cheminform. 32: no-no
Wu HC, Hamid SA, Yu JQ, et al. (2009) Possible origin of electronic effects in Rh(I)-catalyzed enantioselective hydrogenation. Journal of the American Chemical Society. 131: 9604-5
Truman AW, Dias MV, Wu S, et al. (2009) Chimeric glycosyltransferases for the generation of hybrid glycopeptides. Chemistry & Biology. 16: 676-85
Tosin M, Spiteller D, Spencer JB. (2009) Malonyl carba(dethia)- and malonyl oxa(dethia)-coenzyme A as tools for trapping polyketide intermediates. Chembiochem : a European Journal of Chemical Biology. 10: 1714-23
Li TL, Spiteller D, Spencer JB. (2009) Identification of a pentaketide stilbene produced by a type III polyketide synthase from Pinus sylvestris and characterisation of free coenzyme A intermediates. Chembiochem : a European Journal of Chemical Biology. 10: 896-901
Smith L, Hong H, Spencer JB, et al. (2008) Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closure. Chembiochem : a European Journal of Chemical Biology. 9: 2967-75
Fan Q, Huang F, Leadlay PF, et al. (2008) The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase. Organic & Biomolecular Chemistry. 6: 3306-14
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