☰ Chemistry Tree

Frank Sicheri

Affiliations:

Biochemistry

University of Toronto, Toronto, ON, Canada

Area:

protein kinase regulation

Website:

http://biochemistry.utoronto.ca/person/frank-sicheri/

Google:

"Frank Sicheri"

Bio:

http://www.mshri.on.ca/sicheri/

Mean distance: 8.36

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Parents

Daniel S.-C. Yang	grad student	1989-1995	McMaster University
(Ice binding structure and mechanism of an antifreeze protein from winter flounder)
John Kuriyan	post-doc	1995-1997	Rockefeller

Children

Arvin C. Dar	grad student	2006	University of Toronto
Yang-Chieh Chou	grad student	2011	University of Toronto
Thanashan Rajakulendran	grad student	2011	University of Toronto
Dante Neculai	post-doc	2008-2011	Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital (ImmunoTree)

Collaborators

BETA: Related publications

Publications

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Maisonneuve P, Sahmi M, Bergeron-Labrecque F, et al. (2024) The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction. Nature Structural & Molecular Biology
Tessier TM, Chowdhury A, Stekel Z, et al. (2023) Structural and functional validation of a highly specific Smurf2 inhibitor. Protein Science : a Publication of the Protein Society. e4885
Kelso S, O'Brien S, Kurinov I, et al. (2022) Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964. Structure (London, England : 1993). 30: 1615-1625.e4
Beenstock J, Ona SM, Sicheri F. (2022) A suite of in vitro and in vivo assays for monitoring the activity of the pseudokinase Bud32. Methods in Enzymology. 667: 729-773
Veggiani G, Yates BP, Martyn GD, et al. (2022) Panel of Engineered Ubiquitin Variants Targeting the Family of Human Ubiquitin Interacting Motifs. Acs Chemical Biology. 17: 941-956
Beenstock J, Sicheri F. (2021) The structural and functional workings of KEOPS. Nucleic Acids Research. 49: 10818-10834
Tavernier N, Sicheri F, Pintard L. (2021) Aurora A kinase activation: Different means to different ends. The Journal of Cell Biology. 220
Teyra J, McLaughlin M, Singer A, et al. (2021) Comprehensive Assessment of The Relationship Between Site Specificity and Helix α2 in the Erbin PDZ Domain. Journal of Molecular Biology. 167115
Kelso S, Orlicky S, Beenstock J, et al. (2021) Bipartite binding of the N terminus of Skp2 to cyclin A. Structure (London, England : 1993)
Daou S, Talukdar M, Tang J, et al. (2020) A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency. Proceedings of the National Academy of Sciences of the United States of America

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