Zhihong Guo, Ph.D.

2000- Chemistry Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 
Bioorganic chemistry and chemical biology
"Zhihong Guo"
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Ronghui Zhou research assistant 2006-2006 HKUST
Haoqing Wang research assistant 2010-2013
Haigang Song grad student 2010-2014 HKUST
Yaozong Chen grad student 2012-2017 HKUST
Jie Shi grad student 2013-2017 HKUST
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Sun Q, Heater BS, Li TL, et al. (2022) Cry3Aa*SpyCatcher Fusion Crystals Produced in Bacteria as Scaffolds for Multienzyme Coimmobilization. Bioconjugate Chemistry
Jiang Y, Qin M, Guo Z. (2020) Substrate recognition and catalytic mechanism of the phosphate acyltransferase PlsX from Bacillus subtilis. Chembiochem : a European Journal of Chemical Biology
Qin M, Song H, Dai X, et al. (2018) Two active site arginines are critical determinants of substrate binding and catalysis in MenD, a thiamine-dependent enzyme in menaquinone biosynthesis. The Biochemical Journal
Guo Z, Qin M, Song H, et al. (2018) Single turnover kinetics reveal a distinct mode of thiamine diphosphate-dependent catalysis in vitamin K biosynthesis. Chembiochem : a European Journal of Chemical Biology
Chen Y, Li TL, Lin X, et al. (2017) Crystal structure of the thioesterification conformation of Bacillus subtilis o-succinylbenzoyl-CoA synthetase reveals a distinct substrate binding mode. The Journal of Biological Chemistry
Shi J, Cao X, Chen Y, et al. (2016) An Atypical α/β-Hydrolase Fold Revealed in the Crystal Structure of Pimeloyl-Acyl Carrier Protein Methyl Esterase BioG from Haemophilus influenzae. Biochemistry. 55: 6705-6717
Chen Y, Jiang Y, Guo Z. (2016) Mechanistic Insights from the Crystal Structure of Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase Complexed with the Adenylate Intermediate. Biochemistry. 55: 6685-6695
Song H, Dong C, Qin M, et al. (2016) A thiamine-dependent enzyme utilizes an active tetrahedral intermediate in vitamin K biosynthesis. Journal of the American Chemical Society
Song JX, Sun YR, Peluso I, et al. (2016) A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 0
Chen Y, Sun Y, Song H, et al. (2015) Structural Basis for the ATP-dependent Configuration of Adenylation Active Site in Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase. The Journal of Biological Chemistry. 290: 23971-83
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