Jacob Matthew Hooker, Ph.D.

Affiliations: 
1998-2002 Chemistry  North Carolina State University, Raleigh, NC 
 1998-2002 Textile Chemistry North Carolina State University, Raleigh, NC 
 2002-2007 Chemistry University of California, Berkeley, Berkeley, CA 
 2007-2012 Medical Brookhaven National Laboratory, USA 
 2009- Radiology Harvard Medical School, Boston, MA, United States 
 2009- Martinos Center for Biomedical Imaging Massachusetts General Hospital, Boston, MA 
Area:
positron emission tomography, radiotracer chemistry, epigenetics, neuroscience, neurotransmitters
Website:
http://hookerlab.martinos.org/
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SNBCP

Parents

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Matthew B. Francis grad student 2007 UC Berkeley
 (Chemical methods for the construction of biomedical imaging agents from bacteriophage MS2.)
Matthew B. Francis grad student 2007 UC Berkeley
 (Chemical methods for the construction of biomedical imaging agents from bacteriophage MS2.)
Joanna S. Fowler post-doc Brookhaven National Lab
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Publications

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Tseng CJ, Gilbert TM, Catanese MC, et al. (2020) In vivo human brain expression of histone deacetylases in bipolar disorder. Translational Psychiatry. 10: 224
Koole M, Van Weehaeghe D, Serdons K, et al. (2020) Clinical validation of the novel HDAC6 radiotracer [F]EKZ-001 in the human brain. European Journal of Nuclear Medicine and Molecular Imaging
Celen S, Rokka J, Gilbert TM, et al. (2020) Translation of HDAC6 PET imaging using [18F]EKZ-001 - cGMP production and measurement of HDAC6 target occupancy in NHPs. Acs Chemical Neuroscience
Gilbert TM, Zürcher NR, Catanese MC, et al. (2019) Neuroepigenetic signatures of age and sex in the living human brain. Nature Communications. 10: 2945
Gilbert TM, Zürcher NR, Wu CJ, et al. (2018) PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia. The Journal of Clinical Investigation
Placzek MS, Schroeder FA, Che T, et al. (2018) Discrepancies in kappa opioid agonist binding revealed through PET imaging. Acs Chemical Neuroscience
Liu W, Huang X, Placzek MS, et al. (2018) Site-selective F fluorination of unactivated C-H bonds mediated by a manganese porphyrin. Chemical Science. 9: 1168-1172
Weiwer M, Xu Q, Gale JP, et al. (2018) Functionally biased D2R antagonists: Targeting the β-arrestin pathway to improve antipsychotic treatment. Acs Chemical Biology
Krishnan HS, Bernard-Gauthier V, Placzek MS, et al. (2018) A metal protein-attenuating compound for PET neuroimaging: Synthesis and preclinical evaluation of [11C]PBT2. Molecular Pharmaceutics
Schoenberger M, Schroeder FA, Placzek MS, et al. (2017) In vivo [(18)F]GE-179 brain signal does not show NMDA-specific modulation with drug challenges in rodents and non-human primates. Acs Chemical Neuroscience
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