Patrick R. Griffin
Affiliations: | 1989 | Chemistry | University of Virginia, Charlottesville, VA |
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| Frkic RL, Pederick JL, Horsfall AJ, et al. (2023) PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles. Acs Chemical Biology |
| Watson ER, Novick S, Matyskiela ME, et al. (2022) Molecular glue CELMoD compounds are regulators of cereblon conformation. Science (New York, N.Y.). 378: 549-553 |
| Cato ML, Cornelison JL, Spurlin RM, et al. (2022) Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket. Journal of Medicinal Chemistry |
| Strutzenberg TS, Zhu Y, Novick SJ, et al. (2021) Conformational Changes of RORγ During Response Element Recognition and Coregulator Engagement. Journal of Molecular Biology. 167258 |
| Mosure SA, Strutzenberg TS, Shang J, et al. (2021) Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ. Science Advances. 7 |
| Shang J, Mosure SA, Zheng J, et al. (2020) A molecular switch regulating transcriptional repression and activation of PPARγ. Nature Communications. 11: 956 |
| Heidari Z, Chrisman IM, Nemetchek MD, et al. (2019) Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ. Nature Communications. 10: 5825 |
| Shang J, Brust R, Griffin PR, et al. (2019) Quantitative structural assessment of graded receptor agonism. Proceedings of the National Academy of Sciences of the United States of America |
| Strutzenberg TS, Garcia-Ordonez RD, Novick SJ, et al. (2019) HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists. Elife. 8 |
| Doebelin C, He Y, Campbell S, et al. (2019) Discovery and optimization of a series of sulfonamide inverse agonists for the retinoic acid receptor-related receptor-α. Medicinal Chemistry (Shariqah (United Arab Emirates)) |