Amy E. Fraley
Affiliations: | Eidgenössische Technische Hochschule Zürich, Zürich, ZH, Switzerland |
Area:
natural products, biosynthesis, medicinal chemistry, biocatalysisGoogle:
"Amy Fraley"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| David H. Sherman | grad student | 2014-2019 | University of Michigan |
| Janet L. Smith | grad student | 2014-2019 | University of Michigan (Cell Biology Tree) |
| Joern Piel | post-doc | 2019-2023 | ETH Zürich |
Children
Sign in to add trainee| Anita Berg | grad student | 2024- | ETH Zürich |
| Eleonore Moore | grad student | 2024- | ETH Zürich |
| Chad Papenfuhs | grad student | 2024- | ETH Zürich |
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Publications
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| Padhi C, Field CM, Forneris CC, et al. (2024) Metagenomic study of lake microbial mats reveals protease-inhibiting antiviral peptides from a core microbiome member. Proceedings of the National Academy of Sciences of the United States of America. 121: e2409026121 |
| Minas HA, François RMM, Hemmerling F, et al. (2023) Modular oxime formation by a trans-AT polyketide synthase. Angewandte Chemie (International Ed. in English). e202304481 |
| Fraley AE, Dell M, Schmalhofer M, et al. (2023) Heterocomplex structure of a polyketide synthase component involved in modular backbone halogenation. Structure (London, England : 1993). 31: 565-572.e4 |
| Hemmerling F, Meoded RA, Fraley A, et al. (2022) Modular Halogenation, α-Hydroxylation, and Acylation by a Remarkably Versatile Polyketide Synthase. Angewandte Chemie (International Ed. in English) |
| Ye Y, Du L, Zhang X, et al. (2020) Fungal-derived brevianamide assembly by a stereoselective semipinacolase. Nature Catalysis. 3: 497-506 |
| Fraley AE, Tran HT, Kelly SP, et al. (2020) Flavin-Dependent Monooxygenases NotI and NotI' Mediate Spiro-Oxindole Formation in Biosynthesis of the Notoamides. Chembiochem : a European Journal of Chemical Biology |
| Fraley AE, Sherman DH. (2020) Enzyme evolution in fungal indole alkaloid biosynthesis. The Febs Journal |
| Fraley A, Caddell Haatveit K, Ye Y, et al. (2020) Molecular basis for spirocycle formation in the paraherquamide biosynthetic pathway. Journal of the American Chemical Society |
| Dan Q, Newmister SA, Klas KR, et al. (2019) Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase. Nature Chemistry |
| Beyett TS, Fraley AE, Labudde E, et al. (2019) Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe. Proceedings of the National Academy of Sciences of the United States of America |