John R. Engen

Chemistry and Chemical Biology Northeastern University, Boston, MA, United States 
Bioanalytical chemistry, mass spectrometry, hydrogen/deuterium exchange
"John R. Engen"

Asst. Prof. Chemistry, 2002-2006, University of New Mexico, Albuquerque
Assoc. Prof. Chemistry, 2006-2011, Northeastern University, Boston
Prof. Chemistry, 2011-present, Northeastern University, Boston

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Peterle D, Wales TE, Engen JR. (2022) Simple and Fast Maximally Deuterated Control (maxD) Preparation for Hydrogen-Deuterium Exchange Mass Spectrometry Experiments. Analytical Chemistry
Prew MS, Camara CM, Botzanowski T, et al. (2022) Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency. Nature Communications. 13: 3669
Joseph RE, Lowe J, Fulton DB, et al. (2021) The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance. Journal of Molecular Biology. 434: 167422
Ji Z, Li H, Peterle D, et al. (2021) Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase. Molecular Cell
Peterle D, Klimtchuk ES, Wales TE, et al. (2021) A conservative point mutation in a dynamic antigen-binding loop of human immunoglobulin λ6 light chain promotes pathologic amyloid formation. Journal of Molecular Biology. 167310
James EI, Murphree TA, Vorauer C, et al. (2021) Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems. Chemical Reviews
Bloch NB, Wales TE, Prew MS, et al. (2021) The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core. Nature Communications. 12: 4932
Joseph RE, Amatya N, Fulton DB, et al. (2020) Differential impact of BTK active site inhibitors on the conformational state of full-length BTK. Elife. 9
Engen JR, Botzanowski T, Peterle D, et al. (2020) Developments in Hydrogen/Deuterium Exchange Mass Spectrometry. Analytical Chemistry
Staudt RP, Alvarado JJ, Emert-Sedlak LA, et al. (2020) Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes. The Journal of Biological Chemistry
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