John R. Engen

Affiliations: 
Chemistry and Chemical Biology Northeastern University, Boston, MA, United States 
Area:
Bioanalytical chemistry, mass spectrometry, hydrogen/deuterium exchange
Website:
https://neu.hxms.com
Google:
"John R. Engen"
Bio:

Asst. Prof. Chemistry, 2002-2006, University of New Mexico, Albuquerque
Assoc. Prof. Chemistry, 2006-2011, Northeastern University, Boston
Prof. Chemistry, 2011-present, Northeastern University, Boston

Mean distance: 9.82
 
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Publications

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McHenry MW, Shi P, Camara CM, et al. (2024) Covalent inhibition of pro-apoptotic BAX. Nature Chemical Biology
Marie AL, Georgescauld F, Johnson KR, et al. (2024) Native Capillary Electrophoresis-Mass Spectrometry of Near 1 MDa Non-Covalent GroEL/GroES/Substrate Protein Complexes. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2306824
Lin DY, Kueffer LE, Juneja P, et al. (2024) Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife. 12
Joseph RE, Wales TE, Jayne S, et al. (2023) Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia. Biorxiv : the Preprint Server For Biology
Lin DY, Kueffer LE, Juneja P, et al. (2023) Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Biorxiv : the Preprint Server For Biology
A M, Wales TE, Zhou H, et al. (2023) Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α. Molecular Cell. 83: 1903-1920.e12
Ayaz P, Lyczek A, Paung Y, et al. (2023) Structural mechanism of a drug-binding process involving a large conformational change of the protein target. Nature Communications. 14: 1885
Peterle D, DePice D, Wales TE, et al. (2022) Increase the flow rate and improve hydrogen deuterium exchange mass spectrometry. Journal of Chromatography. A. 1689: 463742
Du S, Alvarado JJ, Wales TE, et al. (2022) ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr. Structure (London, England : 1993)
Peterle D, Wales TE, Engen JR. (2022) Simple and Fast Maximally Deuterated Control (maxD) Preparation for Hydrogen-Deuterium Exchange Mass Spectrometry Experiments. Analytical Chemistry
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