John R. Engen
Affiliations: | Chemistry and Chemical Biology | Northeastern University, Boston, MA, United States |
Area:
Bioanalytical chemistry, mass spectrometry, hydrogen/deuterium exchangeWebsite:
https://neu.hxms.comGoogle:
"John R. Engen"Bio:
Asst. Prof. Chemistry, 2002-2006, University of New Mexico, Albuquerque
Assoc. Prof. Chemistry, 2006-2011, Northeastern University, Boston
Prof. Chemistry, 2011-present, Northeastern University, Boston
Mean distance: 9.82 | S | N | B | C | P |
Parents
Sign in to add mentor| David Lee Smith | grad student | 1995-1999 | University of Nebraska - Lincoln |
Children
Sign in to add trainee| Yan Wu | grad student | 2006 | Univ. of New Mexico |
| James M. Hochrein | grad student | 2007 | Univ. of New Mexico |
| Shugui Chen | grad student | 2008 | Northeastern University |
| Damian Houde | grad student | 2010 | Northeastern University |
| Sean R. Marcsisin | grad student | 2011 | Northeastern University |
| Christopher R. Morgan | grad student | 2011 | Northeastern University |
| Joomi Ahn | grad student | 2013 | Northeastern University |
| Gregory Pirrone | grad student | 2016 | Northeastern University |
| Rane Harrison | grad student | 2017 | Northeastern University |
| Brent A. Kochert | grad student | 2018 | Northeastern University |
| Christopher J. Wilson | grad student | 2018 | Northeastern University |
| Thomas Edward Wales | research scientist | 2004- | Northeastern University |
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Publications
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| Peterle D, Wales TE, Engen JR. (2022) Simple and Fast Maximally Deuterated Control (maxD) Preparation for Hydrogen-Deuterium Exchange Mass Spectrometry Experiments. Analytical Chemistry |
| Prew MS, Camara CM, Botzanowski T, et al. (2022) Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency. Nature Communications. 13: 3669 |
| Joseph RE, Lowe J, Fulton DB, et al. (2021) The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance. Journal of Molecular Biology. 434: 167422 |
| Ji Z, Li H, Peterle D, et al. (2021) Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase. Molecular Cell |
| Peterle D, Klimtchuk ES, Wales TE, et al. (2021) A conservative point mutation in a dynamic antigen-binding loop of human immunoglobulin λ6 light chain promotes pathologic amyloid formation. Journal of Molecular Biology. 167310 |
| James EI, Murphree TA, Vorauer C, et al. (2021) Advances in Hydrogen/Deuterium Exchange Mass Spectrometry and the Pursuit of Challenging Biological Systems. Chemical Reviews |
| Bloch NB, Wales TE, Prew MS, et al. (2021) The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core. Nature Communications. 12: 4932 |
| Joseph RE, Amatya N, Fulton DB, et al. (2020) Differential impact of BTK active site inhibitors on the conformational state of full-length BTK. Elife. 9 |
| Engen JR, Botzanowski T, Peterle D, et al. (2020) Developments in Hydrogen/Deuterium Exchange Mass Spectrometry. Analytical Chemistry |
| Staudt RP, Alvarado JJ, Emert-Sedlak LA, et al. (2020) Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes. The Journal of Biological Chemistry |