George Perry, AA, BA, PhD, HonD

Biology The University of Texas at San Antonio, San Antonio, TX, United States 
Alzheimer's disease, oxidative stress, cytoskeleton
"George Perry"

Ph.D., Marine Biology, Scripps Institution of Oceanography, University of California
at San Diego
Postdoctoral Fellow, Department of Cell Biology, Baylor College of Medicine, Houston, Texas

Dr. Perry joined the UTSA faculty in 2006 from Case Western Reserve University where he was Professor of Pathology and Neurosciences and Chair of the Department of Pathology. Perry is distinguished as one of the top twenty Alzheimer’s disease researchers with over 900 publications. He served as Secretary-Treasurer and President for the American Association of Neuropathologists(2009). He also serves as editor for several journals including Journal of Biomedicine and Biotechnology and Microscopy Research and Technique, is on the editorial board of many journals including American Journal of Pathology and Journal of Biological Chemistry, and is Editor-in-Chief of Journal of Alzheimer’s Disease.

Research Interests
Our studies are focused on the mechanism of formation and physiological consequences of the cytopathology of Alzheimer disease. We have shown that oxidative damage is the initial cytopathology in Alzheimer disease. We are working to determine the sequence of events leading to neuronal oxidative damage and the source of the increased oxygen radicals. Our current studies focus on (i) the mechanism for RNA-based redox metal binding; (ii) the consequences of RNA oxidation on protein synthesis rate and fidelity; (iii) the role of redox active metals in mediating prooxidant and antioxidant properties; (iv) the signal transduction pathways altered in Alzheimer disease that allow neurons to evade apoptosis; and (v) mechanism of phosphorylation control of oxidative damage to neurofilament proteins.
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Mean distance: 14.84 (cluster 28)
Cross-listing: Neurotree - Alzheimer's Tree - BCM Tree - Neuropathology Tree


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David Epel grad student 1974-1979 Scripps Oceanography (Neurotree)
William (Bill) R. Brinkley post-doc 1979-1982 Baylor (Neurotree)
Joseph Bryan post-doc 1979-1982 (Neurotree)
Pierluigi C. Gambetti research scientist 1982- Case Western (Neurotree)


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Peggy L. R. Harris research assistant Case Western (Neurotree)
Sandra L. Siedlak research assistant 1988- Case Western (Neurotree)
Robert  L. Russell research assistant 1998-1999 UT San Antonio (Neurotree)
Elizabeth Aguilar Perry research assistant 2010-2012 UT San Antonio (Neurotree)
Richard Nguyen research assistant 2016-2018 UT San Antonio (Neurotree)
Adam Cash grad student Case Western (Neurotree)
Wataru Kudo grad student 2008- UT San Antonio (Neurotree)
David A. DeWitt grad student 1991-1996 Case Western
Avi Friedlich grad student 1997-1997 Case Western (Neurotree)
Takafumi Wataya grad student 1997-1997 Case Western (Neurotree)
Robert  L. Russell grad student 1998-1999 Case Western (Neurotree)
Marta Anne Taddeo grad student 2001-2003 Case Western (Neurotree)
Ya Ke grad student 2002-2004 Case Western (Neurotree)
Quan Liu grad student 2001-2005 Case Western (Neurotree)
Paula Isabel Moreira grad student 2004-2007 Case Western (Neurotree)
Siddhartha Mondragon-Rodriguez grad student 2006-2007 Case Western (Neurotree)
Justin C. Shenk grad student 2006-2008 UT San Antonio
Xinglong Wang grad student 2005-2009 Case Western (Neurotree)
Miguel A. Pappolla post-doc 1985-1986 Case Western (Neurotree)
Valeria Manetto post-doc 1986-1987 Case Western (Neurotree)
Hea-soo Koo post-doc 1987-1987 Case Western (Neurotree)
Pamela G. Galloway post-doc 1986-1988 Case Western (Neurotree)
Massimo Tabaton post-doc 1988-1988 Case Western (Neurotree)
Mitsuru Kawai post-doc 1988-1991 Case Western (Neurotree)
Patrick Cras post-doc 1989-1991 Case Western (Neurotree)
Mark Anthony Smith post-doc 1992-1994 Case Western (Neurotree)
Nancy Tresser post-doc 1992-1994 Case Western (Neurotree)
Darja Praprotnik post-doc 1993-1994 Case Western (Neurotree)
Rudolph J. Castellani post-doc 1994-1995 Case Western (Neurotree)
Keisuke Hirai post-doc 1997-1998 Case Western
Akihiko Nunomura post-doc 1997-1999 Case Western (Neurotree)
Gjumrakch Aliev post-doc 1998-1999 Case Western (Neurotree)
Jiong Shi post-doc 1998-2000 Case Western (Neurotree)
Kazuhiro Honda post-doc 2003-2005 Case Western
Gemma Casadesus post-doc 2003-2006 Case Western (Neurotree)
Craig S. Atwood research scientist Case Western (Neurotree)
Manuel E. Velasco research scientist 1992-1993 Case Western (Neurotree)
Hyoun-Tae Kim research scientist 1999-2000 Case Western (Neurotree)


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Jesus Avila de Grado collaborator Case Western
Richard  L. Bowen collaborator Case Western
Ashley I. Bush collaborator Case Western (Neurotree)
Shu G. Chen collaborator Case Western (Neurotree)
Jack de la Torre collaborator Case Western (Neurotree)
Catarina Resende de Oliveira collaborator Case Western (Neurotree)
Kelly Drew collaborator Case Western
Robert  P. Friedland collaborator Case Western (Neurotree)
Hisashi Fujioka collaborator Case Western (Neurotree)
Hossein A. Ghanbari collaborator Case Western
Barry D. Greenberg collaborator Case Western (Neurotree)
Sami Harik collaborator Case Western (Neurotree)
Khalid Iqbal collaborator Case Western (Neurotree)
James A. Joseph collaborator Case Western (Neurotree)
Rajesh N. Kalaria collaborator Case Western (Neurotree)
Joseph C. LaManna collaborator Case Western (Neurotree)
Ricardo Benjamin Maccioni collaborator UT San Antonio (Neurotree)
Jose Raul Mena-Lopez collaborator Case Western (Neurotree)
Ian Victor Joseph Murray collaborator St Georges University (Neurotree)
Mark E. Obrenovich collaborator Case Western (Neurotree)
Osamu Ogawa collaborator Case Western (Neurotree)
Robert B. Petersen collaborator Case Western (Neurotree)
Arun  K. Raina collaborator Case Western (Neurotree)
Catherine A. Rottcamp collaborator Case Western (Neurotree)
Lawrence M. Sayre collaborator Case Western
Shun Shimohama collaborator Case Western Medical School (Neurotree)
Atsushi Takeda collaborator Case Western
Harry V. Vinters collaborator Case Western (Neurotree)
Xinglong Wang collaborator Case Western (Neurotree)
Peter J. Whitehouse collaborator Case Western (Neurotree)
Mark Anthony Smith collaborator 1994- Case Western (Neurotree)
Xiongwei Zhu collaborator 2002- (Neurotree)
Diego A Forero collaborator 2005- UT San Antonio (GenetiTree)
Gjumrakch Aliev collaborator 1998-2008 UT San Antonio (Neurotree)
BETA: Related publications


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Plascencia-Villa G, Perry G. (2022) Neuropathologic Changes Provide Insights into Key Mechanisms Related to Alzheimer Disease and Related Dementia. The American Journal of Pathology
Ashford JW, Schmitt FA, Bergeron MF, et al. (2022) Now is the Time to Improve Cognitive Screening and Assessment for Clinical and Research Advancement. Journal of Alzheimer's Disease : Jad
Whitehouse P, Gandy S, Saini V, et al. (2022) Making the Case for Accelerated Withdrawal of Aducanumab. Journal of Alzheimer's Disease : Jad
Xolalpa-Cueva L, García-Carlos CA, Villaseñor-Zepeda R, et al. (2022) Hyperphosphorylated Tau Relates to Improved Cognitive Performance and Reduced Hippocampal Excitability in the Young rTg4510 Mouse Model of Tauopathy. Journal of Alzheimer's Disease : Jad
Correia SC, Alves MG, Oliveira PF, et al. (2022) Hypoxic preconditioning averts sporadic Alzheimer's disease-like phenotype in rats: a focus on mitochondria. Antioxidants & Redox Signaling
Mirzayi P, Shobeiri P, Kalantari A, et al. (2022) Optogenetics: implications for Alzheimer's disease research and therapy. Molecular Brain. 15: 20
Sena CM, Seiça R, Perry G. (2022) Editorial: Oxidative Stress Revisited-Major Role in Vascular Diseases, Volume II. Frontiers in Physiology. 12: 826129
Wang Q, Davis PB, Qi X, et al. (2021) Gut-microbiota-microglia-brain interactions in Alzheimer's disease: knowledge-based, multi-dimensional characterization. Alzheimer's Research & Therapy. 13: 177
Wang L, Liu M, Gao J, et al. (2021) Mitochondrial Fusion Suppresses Tau Pathology-Induced Neurodegeneration and Cognitive Decline. Journal of Alzheimer's Disease : Jad
Zheng C, Fillmore NR, Ramos-Cejudo J, et al. (2021) Potential long-term effect of tumor necrosis factor inhibitors on dementia risk: A propensity score matched retrospective cohort study in US veterans. Alzheimer's & Dementia : the Journal of the Alzheimer's Association
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