Ryan A. Herold, DPhil

Affiliations: 
2019-2024 Chemistry University of Oxford, Oxford, United Kingdom 
 2024- Chemistry and Biochemistry University of California, San Diego, La Jolla, CA 
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Parents

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Fraser Armstrong grad student 2019-2023 Oxford
Christopher J. Schofield grad student 2019-2023 Oxford
Faik Akif Tezcan post-doc 2024- UCSD
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Publications

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Megarity CF, Herold RA, Armstrong FA. (2025) Extending protein-film electrochemistry across enzymology and biological inorganic chemistry to investigate, track and control the reactions of non-redox enzymes and spectroscopically silent metals. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry
Herold RA, Schofield CJ, Armstrong FA. (2025) Building Localized NADP(H) Recycling Circuits to Advance Enzyme Cascadetronics. Angewandte Chemie (International Ed. in English). e202414176
Siritanaratkul B, Megarity CF, Herold RA, et al. (2024) Interactive biocatalysis achieved by driving enzyme cascades inside a porous conducting material. Communications Chemistry. 7: 132
Herold RA, Schofield CJ, Armstrong FA. (2023) Electrochemical Nanoreactor Provides a Comprehensive View of Isocitrate Dehydrogenase Cancer-drug Kinetics. Angewandte Chemie (Weinheim An Der Bergstrasse, Germany). 135: e202309149
Herold RA, Schofield CJ, Armstrong FA. (2023) Electrochemical Nanoreactor Provides a Comprehensive View of Isocitrate Dehydrogenase Cancer-drug Kinetics. Angewandte Chemie (International Ed. in English). e202309149
Liu X, Reinbold R, Liu S, et al. (2023) Natural and Synthetic 2-Oxogluturate Derivatives are Substrates for Oncogenic Variants of Human Isocitrate Dehydrogenase 1 and 2. The Journal of Biological Chemistry. 102873
Herold RA, Reinbold R, Schofield CJ, et al. (2022) NADP(H)-dependent biocatalysis without adding NADP(H). Proceedings of the National Academy of Sciences of the United States of America. 120: e2214123120
Armstrong FA, Cheng B, Herold RA, et al. (2022) From Protein Film Electrochemistry to Nanoconfined Enzyme Cascades and the Electrochemical Leaf. Chemical Reviews
Reinbold R, Hvinden IC, Rabe P, et al. (2022) Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors. Nature Communications. 13: 4785
Herold RA, Reinbold R, Megarity CF, et al. (2021) Exploiting Electrode Nanoconfinement to Investigate the Catalytic Properties of Isocitrate Dehydrogenase (IDH1) and a Cancer-Associated Variant. The Journal of Physical Chemistry Letters. 12: 6095-6101
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