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Gregory Douglas Cuny

1992 Pharmacological and Pharmaceutical Sciences University of Houston, Houston, TX, United States 
medicinal chemistry
"Gregory Douglas Cuny"
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Stephen L. Buchwald grad student 1992 MIT
 (The utilisation of zirconium intermediates and the development of hydroformylatlon processes in organic synthesis)
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Delanghe T, Huyghe J, Lee S, et al. (2021) Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor. Cell Death & Disease. 12: 699
Nikhar S, Siokas I, Schlicher L, et al. (2021) Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling. European Journal of Medicinal Chemistry. 215: 113252
Lee S, Ku A, Rao Vippila M, et al. (2020) Mycophenolic anilides as broad specificity inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors. Bioorganic & Medicinal Chemistry Letters. 127543
Cuny GD, Degterev A. (2020) RIPK protein kinase family: Atypical lives of typical kinases. Seminars in Cell & Developmental Biology
Suebsuwong C, Dai B, Pinkas DM, et al. (2020) Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold. European Journal of Medicinal Chemistry. 200: 112417
Pawlowic MC, Somepalli M, Sateriale A, et al. (2019) Genetic ablation of purine salvage in reveals nucleotide uptake from the host cell. Proceedings of the National Academy of Sciences of the United States of America
Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, et al. (2018) Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. Acs Central Science. 4: 1727-1741
Jiang JK, Huang X, Shamim K, et al. (2018) Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors. Bioorganic & Medicinal Chemistry Letters
Ku AF, Cuny GD. (2018) Discovery of 7-hydroxyaporphines as conformationally restricted ligands for beta-1 and beta-2 adrenergic receptors. Medchemcomm. 9: 353-356
Hrdinka M, Schlicher L, Dai B, et al. (2018) Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. The Embo Journal
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