Kuang Shen
Affiliations: | 2013 | Chemistry | California Institute of Technology, Pasadena, CA |
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"Kuang Shen"Mean distance: 9.34 | S | N | B | C | P |
Parents
Sign in to add mentor| Shu-ou Shan | grad student | 2013 | Caltech | |
| (Novel roles of the SRP RNA in co-translational protein targeting.) | ||||
| David M. Sabatini | post-doc | 2013- | Whitehead Institute (MIT), HHMI | |
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Publications
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| Ivanova I, Shen K. (2024) Structures and Functions of the Human GATOR1 Complex. Sub-Cellular Biochemistry. 104: 269-294 |
| Tettoni SD, Egri SB, Doxsey DD, et al. (2023) Structure of the Schizosaccharomyces pombe Gtr-Lam complex reveals evolutionary divergence of mTORC1-dependent amino acid sensing. Structure (London, England : 1993) |
| Doxsey DD, Shen K. (2022) Purification and biochemical characterization of the Rag GTPase heterodimer. Methods in Enzymology. 675: 131-158 |
| Egri S, Ouch C, Chou HT, et al. (2022) Cryo-EM structures of the Human GATOR1-Rag-Ragulator Complex Reveal a Spatial-Constraint Regulated GAP Mechanism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology |
| Egri SB, Ouch C, Chou HT, et al. (2022) Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Molecular Cell |
| Schlingmann KP, Jouret F, Shen K, et al. (2021) mTOR-Activating Mutations in RRAGD are Causative for Kidney Tubulopathy and Cardiomyopathy. Journal of the American Society of Nephrology : Jasn |
| Yurkovetskiy L, Wang X, Pascal KE, et al. (2020) Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant. Cell |
| Shen K, Rogala KB, Chou HT, et al. (2019) Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex. Cell |
| Rasheed N, Lima TB, Mercaldi GF, et al. (2019) C7orf59/Lamtor4 phosphorylation and structural flexibility modulate Ragulator assembly. Febs Open Bio |
| Shen K, Valenstein ML, Gu X, et al. (2019) Arg78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases. The Journal of Biological Chemistry |