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Thomas Edward Wales

2006- Chemistry and Chemical Biology Northeastern University, Boston, MA, United States 
Bioanalytical Chemistry
"Thomas Wales"
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Michael C. Fitzgerald grad student 1998-2003 Duke
 (Total chemical synthesis and biophysical characterization of backbone-modified protein analogues.)
John R. Engen research scientist 2004- Northeastern University
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A M, Wales TE, Zhou H, et al. (2023) Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α. Molecular Cell. 83: 1903-1920.e12
Peterle D, DePice D, Wales TE, et al. (2022) Increase the flow rate and improve hydrogen deuterium exchange mass spectrometry. Journal of Chromatography. A. 1689: 463742
Du S, Alvarado JJ, Wales TE, et al. (2022) ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr. Structure (London, England : 1993)
Peterle D, Wales TE, Engen JR. (2022) Simple and Fast Maximally Deuterated Control (maxD) Preparation for Hydrogen-Deuterium Exchange Mass Spectrometry Experiments. Analytical Chemistry
Prew MS, Camara CM, Botzanowski T, et al. (2022) Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency. Nature Communications. 13: 3669
Joseph RE, Lowe J, Fulton DB, et al. (2021) The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance. Journal of Molecular Biology. 434: 167422
Ji Z, Li H, Peterle D, et al. (2021) Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase. Molecular Cell
Peterle D, Klimtchuk ES, Wales TE, et al. (2021) A conservative point mutation in a dynamic antigen-binding loop of human immunoglobulin λ6 light chain promotes pathologic amyloid formation. Journal of Molecular Biology. 167310
Bloch NB, Wales TE, Prew MS, et al. (2021) The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core. Nature Communications. 12: 4932
Joseph RE, Amatya N, Fulton DB, et al. (2020) Differential impact of BTK active site inhibitors on the conformational state of full-length BTK. Elife. 9
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