Thomas Edward Wales

Affiliations: 
2006- Chemistry and Chemical Biology Northeastern University, Boston, MA, United States 
Area:
Bioanalytical Chemistry
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Parents

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Michael C. Fitzgerald grad student 1998-2003 Duke
 (Total chemical synthesis and biophysical characterization of backbone-modified protein analogues.)
John R. Engen research scientist 2004- Northeastern University
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Publications

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Joseph RE, Wales TE, Jayne S, et al. (2024) Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia. Elife. 13
Selzer AM, Gerlach G, Gonzalez-Areizaga G, et al. (2024) An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck. The Journal of Biological Chemistry. 108088
Rennella E, Henry C, Dickson CJ, et al. (2024) Dynamic conformational equilibria in the active states of KRAS and NRAS. Rsc Chemical Biology
Wales TE, Pajak A, Roeselová A, et al. (2024) Resolving chaperone-assisted protein folding on the ribosome at the peptide level. Nature Structural & Molecular Biology
Woo JR, Bae SH, Wales TE, et al. (2024) The serine phosphorylations in the IRS-1 PIR domain abrogate IRS-1 and IR interaction. Proceedings of the National Academy of Sciences of the United States of America. 121: e2401716121
McHenry MW, Shi P, Camara CM, et al. (2024) Covalent inhibition of pro-apoptotic BAX. Nature Chemical Biology
Lin DY, Kueffer LE, Juneja P, et al. (2024) Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife. 12
Joseph RE, Wales TE, Jayne S, et al. (2023) Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia. Biorxiv : the Preprint Server For Biology
Lin DY, Kueffer LE, Juneja P, et al. (2023) Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Biorxiv : the Preprint Server For Biology
A M, Wales TE, Zhou H, et al. (2023) Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α. Molecular Cell. 83: 1903-1920.e12
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