Gary Loren Kleiger

Affiliations: 
2002 University of California, Los Angeles, Los Angeles, CA 
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"Gary Kleiger"
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David Eisenberg grad student 2002 UCLA
 (Conserved tertiary interactions and alpha-helical interaction motifs in protein structure.)
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Sandoval D, Hill S, Ziemba A, et al. (2015) Ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase (SCF) interact through multiple conformations. The Journal of Biological Chemistry. 290: 1106-18
Huang H, Ceccarelli DF, Orlicky S, et al. (2014) E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin. Nature Chemical Biology. 10: 156-163
Ziemba A, Hill S, Sandoval D, et al. (2013) Multimodal mechanism of action for the Cdc34 acidic loop: a case study for why ubiquitin-conjugating enzymes have loops and tails. The Journal of Biological Chemistry. 288: 34882-96
den Besten W, Verma R, Kleiger G, et al. (2012) NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway. Nature Structural & Molecular Biology. 19: 511-6, S1
Saha A, Lewis S, Kleiger G, et al. (2011) Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate. Molecular Cell. 42: 75-83
Tyrrell A, Flick K, Kleiger G, et al. (2010) Physiologically relevant and portable tandem ubiquitin-binding domain stabilizes polyubiquitylated proteins. Proceedings of the National Academy of Sciences of the United States of America. 107: 19796-801
Pierce NW, Kleiger G, Shan SO, et al. (2009) Detection of sequential polyubiquitylation on a millisecond timescale. Nature. 462: 615-9
Kleiger G, Saha A, Lewis S, et al. (2009) Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates. Cell. 139: 957-68
Petroski MD, Kleiger G, Deshaies RJ. (2006) Evaluation of a diffusion-driven mechanism for substrate ubiquitination by the SCF-Cdc34 ubiquitin ligase complex. Molecular Cell. 24: 523-34
McCarty AS, Kleiger G, Eisenberg D, et al. (2003) Selective dimerization of a C2H2 zinc finger subfamily. Molecular Cell. 11: 459-70
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