Jeffrey A. Sigman, Ph.D.
Affiliations: | 2000 | Chemistry | University of Illinois, Urbana-Champaign, Urbana-Champaign, IL |
| 2002- | Chemistry | St. Mary's College, California, Moraga, CA, United States |
Website:
http://ftp.stmarys-ca.edu/jsigman/Google:
"Jeffrey Sigman"Mean distance: 8.33
Parents
Sign in to add mentor| Yi Lu | grad student | 2000 | UIUC | |
| (Metalloprotein design.) | ||||
| Adele Wolfson | post-doc | 2000-2002 | Wellesley | |
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Publications
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| Bruce LA, Sigman JA, Randall D, et al. (2008) Hydrogen bond residue positioning in the 599-611 loop of thimet oligopeptidase is required for substrate selection. The Febs Journal. 275: 5607-17 |
| Sigman JA, Patwa TH, Tablante AV, et al. (2005) Flexibility in substrate recognition by thimet oligopeptidase as revealed by denaturation studies. The Biochemical Journal. 388: 255-61 |
| Sigman JA, Sharky ML, Walsh ST, et al. (2003) Involvement of surface cysteines in activity and multimer formation of thimet oligopeptidase. Protein Engineering. 16: 623-8 |
| Sigman JA, Edwards SR, Pabon A, et al. (2003) pH dependence studies provide insight into the structure and mechanism of thimet oligopeptidase (EC 3.4.24.15). Febs Letters. 545: 224-8 |
| Sigman JA, Kim HK, Zhao X, et al. (2003) The role of copper and protons in heme-copper oxidases: kinetic study of an engineered heme-copper center in myoglobin. Proceedings of the National Academy of Sciences of the United States of America. 100: 3629-34 |
| Perera R, Sono M, Sigman JA, et al. (2003) Neutral thiol as a proximal ligand to ferrous heme iron: implications for heme proteins that lose cysteine thiolate ligation on reduction. Proceedings of the National Academy of Sciences of the United States of America. 100: 3641-6 |
| Lu Y, Sigman JA, Kim HK, et al. (2003) The role of copper and protons in heme-copper oxidases: Kinetic study of an engineered heme-copper center in myoglobin Journal of Inorganic Biochemistry. 96: 183 |
| Sigman JA, Wang X, Lu Y. (2001) Coupled oxidation of heme by myoglobin is mediated by exogenous peroxide. Journal of the American Chemical Society. 123: 6945-6 |
| Sigman JA, Kwok BC, Lu Y. (2000) From myoglobin to heme-copper oxidase: Design and engineering of a Cu(B) center into sperm whale myoglobin Journal of the American Chemical Society. 122: 8192-8196 |
| Sigman JA, Pond AE, Dawson JH, et al. (1999) Engineering cytochrome c peroxidase into cytochrome P450: a proximal effect on heme-thiolate ligation. Biochemistry. 38: 11122-9 |