Wen-Lian Wu
Affiliations: | Chemistry | Ohio State University, Columbus, Columbus, OH |
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| Wu WL, Burnett DA, Clader J, et al. (2016) Design and synthesis of water soluble β-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters |
| Pissarnitski DA, Zhao Z, Cole D, et al. (2016) Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors. Bioorganic & Medicinal Chemistry |
| Wu WL, Hao J, Domalski M, et al. (2016) Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes. Acs Medicinal Chemistry Letters. 7: 498-501 |
| Zhao Z, Pissarnitski DA, Josien H, et al. (2015) Discovery of a novel, potent spirocyclic series of γ-secretase inhibitors. Journal of Medicinal Chemistry |
| Wu WL, Sasikumar TK, Domalski MS, et al. (2013) A-ring modification of SCH 900229 and related chromene sulfone γ-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 850-3 |
| Wu WL, Asberom T, Bara T, et al. (2013) Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 844-9 |
| Wu WL, Domalski M, Burnett DA, et al. (2012) Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease. Acs Medicinal Chemistry Letters. 3: 892-6 |
| Brumfield S, Korakas P, Silverman LS, et al. (2012) Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain. Bioorganic & Medicinal Chemistry Letters. 22: 7223-6 |
| Bennett CE, Burnett DA, Greenlee WJ, et al. (2012) Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain. Bioorganic & Medicinal Chemistry Letters. 22: 1575-8 |
| Xu R, Cole D, Asberom T, et al. (2011) SAR of tricyclic sulfones as γ-secretase inhibitors Science China Chemistry. 54: 1688-1701 |