☰ Chemistry Tree

Stephen G. Withers

Affiliations:

1982-2000

Chemistry

University of British Columbia, Vancouver, Vancouver, BC, Canada

Area:

enzyme mechanisms, protein structure/function relationships, enzyme inhibitor design/synthesis and protein engineering

Website:

https://www.chem.ubc.ca/stephen-withers

Google:

"Stephen Withers"

Bio:

http://www.chibi.ubc.ca/faculty/stephen-g-withers/
http://www.chibi.ubc.ca/faculty/stephen-g-withers/withers/
http://www.chibi.ubc.ca/faculty/stephen-g-withers/withers-lab/
http://www.chibi.ubc.ca/faculty/stephen-g-withers/withers-lab/s-withers/
http://withers.chem.ubc.ca/past-members/

Mean distance: 8.27

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Parents

Michael L. Sinnott	grad student	1977	University of Bristol
Neil Bernard Madsen	post-doc	1978-1982	University of Alberta
Brian D. Sykes	post-doc	1978-1982	University of Alberta

Children

M David Percival	grad student	1988	UBC
Edwin H. Rydberg	grad student	2000	UBC
Alexander W. Wong	grad student	2001	UBC
Carl S. Rye	grad student	2002	UBC
David J. Vocadlo	grad student	2002	UBC
Shin Numao	grad student	2003	UBC
Luke L. Lairson	grad student	2002-2007	UBC
Matthew B. C. Calvert	post-doc		(Microtree)
Ethan Goddard-Borger	post-doc		UBC (Crystallography Tree)
Zhizeng Gao	post-doc	2014-	UBC
Vito Ferro	post-doc	1994-1996	UBC
Spencer John Williams	post-doc	1999-2000	UBC
David H. Kwan	post-doc	2009-2015	UBC

Collaborators

BETA: Related publications

Publications

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Calvert M, Sweeney RP, Chen HM, et al. (2023) Branched montbretin A mimics allow derivatisation and potent amylase inhibition. Organic & Biomolecular Chemistry. 21: 7977-7983
Prasch H, Wolfsgruber A, Thonhofer M, et al. (2023) Ligand-Directed Chemistry on Glycoside Hydrolases - A Proof of Concept Study. Chembiochem : a European Journal of Chemical Biology. 24: e202300480
Danby PM, Jeong A, Sim L, et al. (2023) Vinyl Halide-Modified Unsaturated Cyclitols are Mechanism-Based Glycosidase Inhibitors. Angewandte Chemie (International Ed. in English). e202301258
Hunter C, Gao Z, Chen HM, et al. (2022) Attenuation of Polysialic Acid Biosynthesis in Cells by the Small Molecule Inhibitor 8-Keto-sialic acid. Acs Chemical Biology. 18: 41-48
Santana A, Robinson K, Vickers C, et al. (2022) Pharmacological Chaperones for GCase That Switch Conformation with pH Enhance Enzyme Levels in Gaucher Animal Models. Angewandte Chemie (International Ed. in English)
Tegl G, Rahfeld P, Ostmann K, et al. (2021) Discovery of β--acetylglucosaminidases from screening metagenomic libraries and their use as thioglycoligase mutants. Organic & Biomolecular Chemistry
Gao J, Klenow L, Parsons L, et al. (2021) Design of the Recombinant Influenza Neuraminidase Antigen is Crucial for its Biochemical Properties and Protective Efficacy. Journal of Virology. JVI0116021
Li J, Solhi L, Goddard-Borger ED, et al. (2021) Four cellulose-active lytic polysaccharide monooxygenases from Cellulomonas species. Biotechnology For Biofuels. 14: 29
Harmsen RAG, Aam BB, Madhuprakash J, et al. (2020) Chemoenzymatic Synthesis of Chito-oligosaccharides with Alternating -d-Acetylglucosamine and d-Glucosamine. Biochemistry. 59: 4581-4590
Fonseca MJMD, Armstrong Z, Withers SG, et al. (2020) High-throughput generation of product profiles for arabinoxylan-active enzymes from metagenomes. Applied and Environmental Microbiology

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