Harold Kohn

1973-1999 Chemistry University of Houston, Houston, TX, United States 
 1999- Medicinal Chemistry University of North Carolina, Chapel Hill, Chapel Hill, NC 
biological mechanisms of therapeutic agents
"Harold Kohn"


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Lee H, Park KD, Torregrosa R, et al. (2014) Substituted N-(biphenyl-4'-yl)methyl (R)-2-acetamido-3-methoxypropionamides: potent anticonvulsants that affect frequency (use) dependence and slow inactivation of sodium channels. Journal of Medicinal Chemistry. 57: 6165-82
Lee H, Gold AS, Yang XF, et al. (2013) Benzyloxybenzylammonium chlorides: Simple amine salts that display anticonvulsant activity. Bioorganic & Medicinal Chemistry. 21: 7655-62
Park KD, Yang XF, Lee H, et al. (2013) Discovery of lacosamide affinity bait agents that exhibit potent voltage-gated sodium channel blocking properties. Acs Chemical Neuroscience. 4: 463-74
King AM, Yang XF, Wang Y, et al. (2012) Identification of the benzyloxyphenyl pharmacophore: a structural unit that promotes sodium channel slow inactivation. Acs Chemical Neuroscience. 3: 1037-49
Baruah PK, Dinsmore J, King AM, et al. (2012) Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides. Bioorganic & Medicinal Chemistry. 20: 3551-64
King AM, De Ryck M, Kaminski R, et al. (2011) Defining the structural parameters that confer anticonvulsant activity by the site-by-site modification of (R)-N'-benzyl 2-amino-3-methylbutanamide. Journal of Medicinal Chemistry. 54: 6432-42
King AM, Salomé C, Salomé-Grosjean E, et al. (2011) Primary amino acid derivatives: substitution of the 4'-N'-benzylamide site in (R)-N'-benzyl 2-amino-3-methylbutanamide, (R)-N'-benzyl 2-amino-3,3-dimethylbutanamide, and (R)-N'-benzyl 2-amino-3-methoxypropionamide provides potent anticonvulsants with pain-attenuating properties. Journal of Medicinal Chemistry. 54: 6417-31
Wang Y, Wilson SM, Brittain JM, et al. (2011) Merging Structural Motifs of Functionalized Amino Acids and α-Aminoamides Results in Novel Anticonvulsant Compounds with Significant Effects on Slow and Fast Inactivation of Voltage-gated Sodium Channels and in the Treatment of Neuropathic Pain. Acs Chemical Neuroscience. 2: 317-322
Park KD, Kim D, Reamtong O, et al. (2011) Identification of a lacosamide binding protein using an affinity bait and chemical reporter strategy: 14-3-3 ζ. Journal of the American Chemical Society. 133: 11320-30
King AM, Salomé C, Dinsmore J, et al. (2011) Primary amino acid derivatives: compounds with anticonvulsant and neuropathic pain protection activities. Journal of Medicinal Chemistry. 54: 4815-30
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