☰ Chemistry Tree

Harold Kohn

Affiliations:	1973-1999	Chemistry	University of Houston, Houston, TX, United States
	1999-	Medicinal Chemistry	University of North Carolina, Chapel Hill, Chapel Hill, NC

Area:

biological mechanisms of therapeutic agents

Website:

http://www.chem.unc.edu/research/index.html?display=organic&content=kohn

Google:

Bio:

http://imageserve.chem.unc.edu/resources/pdf_files/faculty_cv/kohn/kohn_cv.pdf

Mean distance: 6.95

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Parents

Raymond E. Counsell	research assistant	1962-1966	University of Michigan
Roy Arne Olofson	grad student	1966-1971	Penn State
Ronald Charles David Breslow	post-doc	1971-1973	Columbia

Children

Mary Beth Bean	grad student	1983	University of Houston
Arnaud Le Tiran	grad student	2000	University of Houston
Younghwa Na	grad student	2000	University of Houston
Andrew P. Brogan	grad student	2004	UNC Chapel Hill
Wujian Ju	grad student	2009	UNC Chapel Hill
Pierre P. Morieux	grad student	2010	UNC Chapel Hill
Amber M. King	grad student	2011	UNC Chapel Hill

Collaborators

BETA: Related publications

Publications

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Lee H, Park KD, Torregrosa R, et al. (2014) Substituted N-(biphenyl-4'-yl)methyl (R)-2-acetamido-3-methoxypropionamides: potent anticonvulsants that affect frequency (use) dependence and slow inactivation of sodium channels. Journal of Medicinal Chemistry. 57: 6165-82
Lee H, Gold AS, Yang XF, et al. (2013) Benzyloxybenzylammonium chlorides: Simple amine salts that display anticonvulsant activity. Bioorganic & Medicinal Chemistry. 21: 7655-62
Park KD, Yang XF, Lee H, et al. (2013) Discovery of lacosamide affinity bait agents that exhibit potent voltage-gated sodium channel blocking properties. Acs Chemical Neuroscience. 4: 463-74
King AM, Yang XF, Wang Y, et al. (2012) Identification of the benzyloxyphenyl pharmacophore: a structural unit that promotes sodium channel slow inactivation. Acs Chemical Neuroscience. 3: 1037-49
Baruah PK, Dinsmore J, King AM, et al. (2012) Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides. Bioorganic & Medicinal Chemistry. 20: 3551-64
King AM, De Ryck M, Kaminski R, et al. (2011) Defining the structural parameters that confer anticonvulsant activity by the site-by-site modification of (R)-N'-benzyl 2-amino-3-methylbutanamide. Journal of Medicinal Chemistry. 54: 6432-42
King AM, Salomé C, Salomé-Grosjean E, et al. (2011) Primary amino acid derivatives: substitution of the 4'-N'-benzylamide site in (R)-N'-benzyl 2-amino-3-methylbutanamide, (R)-N'-benzyl 2-amino-3,3-dimethylbutanamide, and (R)-N'-benzyl 2-amino-3-methoxypropionamide provides potent anticonvulsants with pain-attenuating properties. Journal of Medicinal Chemistry. 54: 6417-31
Wang Y, Wilson SM, Brittain JM, et al. (2011) Merging Structural Motifs of Functionalized Amino Acids and α-Aminoamides Results in Novel Anticonvulsant Compounds with Significant Effects on Slow and Fast Inactivation of Voltage-gated Sodium Channels and in the Treatment of Neuropathic Pain. Acs Chemical Neuroscience. 2: 317-322
Park KD, Kim D, Reamtong O, et al. (2011) Identification of a lacosamide binding protein using an affinity bait and chemical reporter strategy: 14-3-3 ζ. Journal of the American Chemical Society. 133: 11320-30
King AM, Salomé C, Dinsmore J, et al. (2011) Primary amino acid derivatives: compounds with anticonvulsant and neuropathic pain protection activities. Journal of Medicinal Chemistry. 54: 4815-30

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