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Michael P. Pollastri, Ph.D.

Affiliations: 
1998-2007 Pfizer, Inc., San Diego, CA, United States 
 2009- Chemistry Northeastern University, Boston, MA, United States 
Area:
Medicinal chemistry, neglected tropical diseases
Website:
http://www.northeastern.edu/pollastri/mike/
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"Michael Pollastri"
Mean distance: 8.43
 
SNBCP

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Kathlyn A. Parker grad student 2000-2004 Brown
 (Applications of ruthenium-catalyzed olefin metathesis to the preparation of fused ring systems.)
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Publications

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Klug DM, Mavrogiannaki EM, Forbes KC, et al. (2021) Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis. Journal of Medicinal Chemistry
Klug DM, Diaz-Gonzalez R, DeLano TJ, et al. (2020) Structure-property studies of an imidazoquinoline chemotype with antitrypanosomal activity. Rsc Medicinal Chemistry. 11: 950-959
Singh B, Diaz-Gonzalez R, Ceballos-Perez G, et al. (2020) Medicinal Chemistry Optimization of a Diaminopurine Chemotype: Toward a Lead for Inhibitors. Journal of Medicinal Chemistry
Buskes MJ, Clements M, Bachovchin KA, et al. (2020) Structure-Bioactivity Relationships of Lapatinib Derived Analogs against . Acs Medicinal Chemistry Letters. 11: 258-265
Singh B, Bernatchez JA, McCall LI, et al. (2020) Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors. Acs Medicinal Chemistry Letters. 11: 249-257
Tear W, Bag S, Díaz González R, et al. (2019) Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis. Journal of Medicinal Chemistry
Klug DM, Tschiegg L, Díaz González R, et al. (2019) Hit-to-lead optimization of benzoxazepinoindazoles as human African trypanosomiasis therapeutics. Journal of Medicinal Chemistry
Klug DM, Diaz-Gonzalez R, Pérez-Moreno G, et al. (2019) Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents. Plos Neglected Tropical Diseases. 13: e0007129
Bachovchin KA, Sharma A, Bag S, et al. (2018) Improvement of Aqueous Solubility of Lapatinib-derived Analogs: Identification of a Quinolinimine as a Lead for Human African Trypanosomiasis Drug Development. Journal of Medicinal Chemistry
Ferrins L, Sharma A, Thomas SM, et al. (2018) Anilinoquinoline based inhibitors of trypanosomatid proliferation. Plos Neglected Tropical Diseases. 12: e0006834
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