Everette L. May, Ph.D.

1941-1977 National Institutes of Health, Bethesda, MD 
"Everette May"

1979 ACS Medicinal Chemistry Hall of Fame

Mean distance: 10.64
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Metcalf MD, Aceto MD, Harris LS, et al. (2008) The influence of esters and carboxylic acids as the N-substituent of opioids. Part 1: Benzomorphans. Bioorganic & Medicinal Chemistry. 16: 869-73
Hiebel AC, Lee YS, Bilsky E, et al. (2007) Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorphan series. Journal of Medicinal Chemistry. 50: 3765-76
Aceto MD, May EL, Harris LS, et al. (2007) Pharmacological studies with a nonpeptidic, delta-opioid (-)-(1R,5R,9R)-5,9-dimethyl-2'-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride ((-)-NIH 11082). European Journal of Pharmacology. 566: 88-93
Cheng K, Kim IJ, Lee MJ, et al. (2007) Opioid ligands with mixed properties from substituted enantiomeric N-phenethyl-5-phenylmorphans. Synthesis of a micro-agonist delta-antagonist and delta-inverse agonists. Organic & Biomolecular Chemistry. 5: 1177-90
Damaj MI, Flood P, Ho KK, et al. (2005) Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity. The Journal of Pharmacology and Experimental Therapeutics. 312: 780-5
Thompson CM, Wojno H, Greiner E, et al. (2004) Activation of G-proteins by morphine and codeine congeners: insights to the relevance of O- and N-demethylated metabolites at mu- and delta-opioid receptors. The Journal of Pharmacology and Experimental Therapeutics. 308: 547-54
May EL, Coop A, Woods JH, et al. (2003) N-(trifluoromethyl)benzyl substituted N-normetazocines and N-norketobemidones. Bioorganic & Medicinal Chemistry. 11: 31-3
Newman JL, Vann RE, May EL, et al. (2002) Heroin discriminative stimulus effects of methadone, LAAM and other isomers of acetylmethadol in rats. Psychopharmacology. 164: 108-14
May EL, Jacobson AE, Mattson MV, et al. (2000) Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues. Journal of Medicinal Chemistry. 43: 5030-6
May EL, Aceto MD, Bowman ER, et al. (2000) Enantiomeric (-)-(1R,5R,9R) and (+)-(1S,5S,9S) heterocyclic N-substituted-normetazocines: Synthesis of potent and selective antinociceptives and opioid antagonists through N-substituent modification Medicinal Chemistry Research. 10: 178-185
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