Paul J. Coleman

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1994 Indiana University, Bloomington, Bloomington, IN, United States 
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Raheem IT, Schreier JD, Fuerst J, et al. (2015) Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia. Bioorganic & Medicinal Chemistry Letters
Hostetler ED, Fan H, Joshi AD, et al. (2015) Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [(11)C]MK-8193. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging
Raheem I, Walji A, Klein D, et al. (2015) Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors. Journal of Medicinal Chemistry
Shipe WD, Sharik SS, Barrow JC, et al. (2015) Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis. Journal of Medicinal Chemistry
Roecker AJ, Cox CD, Coleman PJ. (2015) Orexin Receptor Antagonists: New Therapeutic Agents for the Treatment of Insomnia. Journal of Medicinal Chemistry
Cox CD, Hostetler ED, Flores BA, et al. (2015) Discovery of [(11)C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors. Bioorganic & Medicinal Chemistry Letters
Kuduk SD, Skudlarek JW, DiMarco CN, et al. (2015) Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties. Bioorganic & Medicinal Chemistry Letters. 25: 2488-92
Rudd MT, Butcher JW, Nguyen KT, et al. (2015) P2-quinazolinones and bis-macrocycles as new templates for next-generation hepatitis C virus NS3/4a protease inhibitors: discovery of MK-2748 and MK-6325. Chemmedchem. 10: 727-35
Roecker AJ, Mercer SP, Bergman JM, et al. (2015) Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements. Bioorganic & Medicinal Chemistry Letters
Raheem IT, Breslin MJ, Bruno J, et al. (2015) Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant. Bioorganic & Medicinal Chemistry Letters. 25: 444-50
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