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Chiara Rose Valenzano, Ph.D.

Affiliations: 
2004-2010 Brown University, Providence, RI 
Website:
http://casey.brown.edu/chemistry/research/dec/resgrp/
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"Chiara Valenzano"
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Parents

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David E. Cane grad student 2004-2010 Brown
Christopher Abell post-doc 2010-2013 Cambridge
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Publications

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Scott DE, Francis-Newton NJ, Marsh ME, et al. (2021) A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell Chemical Biology
Valenzano CR, You YO, Garg A, et al. (2010) Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase. Journal of the American Chemical Society. 132: 14697-9
Guo X, Liu T, Valenzano CR, et al. (2010) Mechanism and stereospecificity of a fully saturating polyketide synthase module: nanchangmycin synthase module 2 and its dehydratase domain. Journal of the American Chemical Society. 132: 14694-6
Valenzano CR, Lawson RJ, Chen AY, et al. (2009) The biochemical basis for stereochemical control in polyketide biosynthesis. Journal of the American Chemical Society. 131: 18501-11
Castonguay R, Valenzano CR, Chen AY, et al. (2008) Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase. Journal of the American Chemical Society. 130: 11598-9
Liu T, You D, Valenzano C, et al. (2006) Identification of NanE as the thioesterase for polyether chain release in nanchangmycin biosynthesis. Chemistry & Biology. 13: 945-55
Wu J, Zaleski TJ, Valenzano C, et al. (2005) Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase. Journal of the American Chemical Society. 127: 17393-404
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