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Philip S. Portoghese, Ph.D.

1962- Pharmacy University of Minnesota, Twin Cities, Minneapolis, MN 
Medicinal Chemistry
"Philip Salvatore Portoghese"
ACS Medicinal Chemistry Hall of Fame, 1990

Mean distance: 9953.25


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Edward Ervin Smissman grad student 1961 UW Madison
 (Podophyllum components: synthetic approaches.)


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Maria Laura Bolognesi research assistant 1994-1994 School of Pharmacy
Joseph George Turcotte grad student 1967 UMN
Sathit Niratisai grad student 2003 UMN
David S. Daniels grad student 2006 UMN
Ajay S. Yekkirala grad student 2011 UMN
Jane V. Aldrich post-doc 1984-1986 UMN
Robert M. Jones post-doc 1996-1998 UMN
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Akgün E, Javed MI, Lunzer MM, et al. (2015) Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5). Journal of Medicinal Chemistry
Smeester BA, Lunzer MM, Akgün E, et al. (2014) Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model. European Journal of Pharmacology. 743: 48-52
Le Naour M, Lunzer MM, Powers MD, et al. (2014) Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects. Journal of Medicinal Chemistry. 57: 6383-92
Akgün E, Javed MI, Lunzer MM, et al. (2013) Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception. Proceedings of the National Academy of Sciences of the United States of America. 110: 11595-9
Le Naour M, Akgün E, Yekkirala A, et al. (2013) Bivalent ligands that target μ opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance. Journal of Medicinal Chemistry. 56: 5505-13
Yekkirala AS, Kalyuzhny AE, Portoghese PS. (2013) An immunocytochemical-derived correlate for evaluating the bridging of heteromeric mu-delta opioid protomers by bivalent ligands. Acs Chemical Biology. 8: 1412-6
Pravetoni M, Le Naour M, Tucker AM, et al. (2013) Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens. Journal of Medicinal Chemistry. 56: 915-23
Yekkirala AS, Banks ML, Lunzer MM, et al. (2012) Clinically employed opioid analgesics produce antinociception via μ-δ opioid receptor heteromers in Rhesus monkeys. Acs Chemical Neuroscience. 3: 720-7
Metcalf MD, Yekkirala AS, Powers MD, et al. (2012) The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors. Acs Chemical Neuroscience. 3: 505-9
Pravetoni M, Raleigh MD, Le Naour M, et al. (2012) Co-administration of morphine and oxycodone vaccines reduces the distribution of 6-monoacetylmorphine and oxycodone to brain in rats. Vaccine. 30: 4617-24
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