Ajay S. Yekkirala, PhD

Affiliations: 
2007-2011 Pharmacology University of Minnesota, Twin Cities, Minneapolis, MN 
 2011-2018 Neurobiology Harvard Medical School - Boston Children's Hospital 
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"Ajay Yekkirala"
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Parents

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Philip S. Portoghese grad student 2011 UMN
 (Elucidating the role of opioid receptor heteromers as targets for analgesic drug design.)
Clifford Woolf post-doc 2011-2018 (Neurotree)
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Publications

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Talbot S, Doyle B, Huang J, et al. (2020) Vagal sensory neurons drive mucous cell metaplasia. The Journal of Allergy and Clinical Immunology
Yekkirala AS, Roberson DP, Bean BP, et al. (2017) Breaking barriers to novel analgesic drug development. Nature Reviews. Drug Discovery
Yekkirala AS, Roberson DP, Bean BP, et al. (2017) Breaking barriers to novel analgesic drug development. Nature Reviews. Drug Discovery
Sisignano M, Angioni C, Park CK, et al. (2016) Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America
Chandran V, Coppola G, Nawabi H, et al. (2016) A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program. Neuron
Le Naour M, Akgün E, Yekkirala A, et al. (2013) Bivalent ligands that target μ opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance. Journal of Medicinal Chemistry. 56: 5505-13
Yekkirala AS, Kalyuzhny AE, Portoghese PS. (2013) An immunocytochemical-derived correlate for evaluating the bridging of heteromeric mu-delta opioid protomers by bivalent ligands. Acs Chemical Biology. 8: 1412-6
Yekkirala AS. (2013) Two to tango: GPCR oligomers and GPCR-TRP channel interactions in nociception. Life Sciences. 92: 438-45
Yekkirala AS, Banks ML, Lunzer MM, et al. (2012) Clinically employed opioid analgesics produce antinociception via μ-δ opioid receptor heteromers in Rhesus monkeys. Acs Chemical Neuroscience. 3: 720-7
Metcalf MD, Yekkirala AS, Powers MD, et al. (2012) The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors. Acs Chemical Neuroscience. 3: 505-9
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